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Gene Expression Profiling of Hepatocellular Carcinoma Derived Cancer Stem Like Cell under Hypoxia.

DC Field Value Language
dc.contributor.author김경식-
dc.contributor.author안상훈-
dc.date.accessioned2018-07-20T08:12:30Z-
dc.date.available2018-07-20T08:12:30Z-
dc.date.issued2017-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160964-
dc.description.abstractPURPOSE: Cancer stem like cells (CSCs), with unlimited self-renewal potential and other stem cell characteristics, occur in several cancers including hepatocellular carcinoma (HCC). Although CSCs can initiate tumors, malignant proliferation, relapse and multi-drug resistance, the ways how to activate them still remain unknown. This study aims to evaluate whether CSC acquire tumorigenic characters under tumor hypoxia, analyzed by microarray analysis. MATERIALS AND METHODS: CSCs were purified from HCC patients and Affymetrix microarray was used to investigate their gene expression profiles. The results were validated by real-time polymerase chain reaction (PCR). RESULTS: The results of the microarray indicated that 18 genes were up-regulated and 10 genes were down-regulated in CSCs. Several genes were identified to be significantly involved in the regulation of CSCs such as HCC. Furthermore, the up-regulated genes were related with metabolism, angiogenesis and hypoxia, whereas the down-regulated genes were related with apoptosis and inflammation. CONCLUSION: The results may help to understand the mechanisms of tumor development through CSCs which acquired their distinctive tumorogenic properties by hypoxic stimulation.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCarcinoma, Hepatocellular/genetics*-
dc.subject.MESHCarcinoma, Hepatocellular/pathology-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHGene Expression Profiling*-
dc.subject.MESHGene Expression Regulation, Neoplastic*-
dc.subject.MESHHumans-
dc.subject.MESHHypoxia/complications*-
dc.subject.MESHHypoxia/genetics-
dc.subject.MESHLiver Neoplasms/genetics*-
dc.subject.MESHLiver Neoplasms/pathology*-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHNeoplastic Stem Cells/metabolism-
dc.subject.MESHNeoplastic Stem Cells/pathology*-
dc.subject.MESHReal-Time Polymerase Chain Reaction-
dc.subject.MESHReproducibility of Results-
dc.titleGene Expression Profiling of Hepatocellular Carcinoma Derived Cancer Stem Like Cell under Hypoxia.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorSung Hoon Choi-
dc.contributor.googleauthorSang Woo Lee-
dc.contributor.googleauthorMinseon Ok-
dc.contributor.googleauthorKyung Sik Kim-
dc.contributor.googleauthorSungsik Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.identifier.doi10.3349/ymj.2017.58.5.925-
dc.contributor.localIdA00299-
dc.contributor.localIdA02226-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid28792135-
dc.subject.keywordHypoxia-
dc.subject.keywordcancer stem cell-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordmicroarray-
dc.contributor.alternativeNameKim, Kyung Sik-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.affiliatedAuthorKim, Kyung Sik-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.citation.volume58-
dc.citation.number5-
dc.citation.startPage925-
dc.citation.endPage933-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.58(5) : 925-933, 2017-
dc.identifier.rimsid60858-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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