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Mechanical compression induces VEGFA overexpression in breast cancer via DNMT3A-dependent miR-9 downregulation

DC FieldValueLanguage
dc.contributor.author강숙희-
dc.contributor.author조남훈-
dc.contributor.author김백길-
dc.contributor.author한현호-
dc.date.accessioned2018-07-20T08:12:19Z-
dc.date.available2018-07-20T08:12:19Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160960-
dc.description.abstractTumor growth generates mechanical compression, which may trigger mechanotransduction in cancer and stromal cells and promote tumor progression. However, very little is known about how compression stimulates signal transduction and contributes to tumor progression. In the present study, we demonstrated that compression enhances a tumor progression phenotype using an in vitro compression model, and validated the results from the in vitro model with high- and low-compressed breast cancer tissues. Mechanical compression induced miR-9 downregulation by DNMT3A-dependent promoter methylation in the MDA-MB-231 and BT-474 breast cancer cell lines and in cancer-associated fibroblasts. The overexpression of miR-9 target genes (LAMC2, ITGA6, and EIF4E) was induced by miR-9 downregulation, which eventually enhanced vascular endothelial growth factors production. Demethylation and decompression could reverse compression-induced miR-9 downregulation and following overexpression of miR-9 target genes and VEGFA.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfCell Death & Disease-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBreast Neoplasms/genetics*-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHDNA (Cytosine-5-)-Methyltransferases/genetics*-
dc.subject.MESHDNA Methylation/genetics-
dc.subject.MESHDisease Progression-
dc.subject.MESHDown-Regulation/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHFibroblasts/pathology-
dc.subject.MESHGene Expression Regulation, Neoplastic/genetics-
dc.subject.MESHHumans-
dc.subject.MESHMCF-7 Cells-
dc.subject.MESHMechanotransduction, Cellular/genetics-
dc.subject.MESHMicroRNAs/genetics*-
dc.subject.MESHPromoter Regions, Genetic/genetics-
dc.subject.MESHSignal Transduction/genetics-
dc.subject.MESHVascular Endothelial Growth Factor A/genetics*-
dc.titleMechanical compression induces VEGFA overexpression in breast cancer via DNMT3A-dependent miR-9 downregulation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorBaek Gil Kim-
dc.contributor.googleauthorMing-Qing Gao-
dc.contributor.googleauthorSuki Kang-
dc.contributor.googleauthorYoon Pyo Choi-
dc.contributor.googleauthorJoo Hyun Lee-
dc.contributor.googleauthorJi Eun Kim-
dc.contributor.googleauthorHyun Ho Han-
dc.contributor.googleauthorSeong Gyeong Mun-
dc.contributor.googleauthorNam Hoon Cho-
dc.identifier.doi10.1038/cddis.2017.73-
dc.contributor.localIdA00044-
dc.contributor.localIdA03812-
dc.relation.journalcodeJ00482-
dc.identifier.eissn2041-4889-
dc.identifier.pmid28252641-
dc.contributor.alternativeNameKang, Suki-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.affiliatedAuthorKang, Suki-
dc.contributor.affiliatedAuthorCho, Nam Hoon-
dc.citation.volume8-
dc.citation.number3-
dc.citation.startPagee2646-
dc.identifier.bibliographicCitationCell Death & Disease, Vol.8(3) : e2646, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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