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Nodal metastasis signatures in breast cancer

DC FieldValueLanguage
dc.contributor.author강숙희-
dc.contributor.author구자승-
dc.contributor.author조남훈-
dc.contributor.author차윤진-
dc.contributor.author한현호-
dc.date.accessioned2018-07-20T08:12:14Z-
dc.date.available2018-07-20T08:12:14Z-
dc.date.issued2017-
dc.identifier.issn0344-0338-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160959-
dc.description.abstractAlthough the molecular taxonomy of invasive breast cancer is based on heterogeneous histologic types, pathologic nodal (pN) stage remains one of the most important independent prognostic factors. Although node-positive number (NPN) has been widely as an accepted staging algorithm of pN stage, the node-positive ratio (NPR) in totally resected axillary nodes has been considered as another reasonable indicator. We aimed to identify signatures to play a predictive role in nodal metastasis for analytic validation between the primary breast cancers with positive node metastasis and those with negative node metastasis. We validated expression profiles of surrogate candidates extracted from the prior 2D MALDI-TOF data for invasive breast cancer using fluorescence/silver in situ hybridization (FISH/SISH) and immunohistochemistry (IHC) in 151 primary breast cancers accompanied with 102 metastatic nodal tissues. Cox proportional hazards regression analyses indicated that event factors (recurrence or metastasis) were significantly more frequent in cases with CCDN1, c-myc gene amplification, IgHA2 low expression. CCDN1 gene amplification (OR: 5.702, p=0.0006), IgHA2 low expression (OR: 0.16, p=0.0184) remained significant factors for events on multivariate analyses. WDR+/ERK++ was significantly detected in higher pN stage (averaging 6.5 regional nodes or 43% of NPR), while seldom found in pN0-1. In conclusion, both overexpression of WDR1 and p-ERK in the primary breast cancer could play a role in the nodal signature over pN2-3.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish, German, French, English(Summary), German(Summary)-
dc.publisherGustav Fischer Verlag-
dc.relation.isPartOfPathology Research and Practice-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor-
dc.subject.MESHBreast Neoplasms/metabolism-
dc.subject.MESHBreast Neoplasms/mortality-
dc.subject.MESHBreast Neoplasms/pathology*-
dc.subject.MESHCarcinoma, Ductal, Breast/metabolism-
dc.subject.MESHCarcinoma, Ductal, Breast/pathology*-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHExtracellular Signal-Regulated MAP Kinases/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHGenes, myc-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHIn Situ Hybridization/methods-
dc.subject.MESHLymph Node Excision-
dc.subject.MESHLymphatic Metastasis/pathology*-
dc.subject.MESHMicrofilament Proteins/metabolism-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPhosphorylation-
dc.subject.MESHSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization-
dc.subject.MESHSurvival Rate-
dc.titleNodal metastasis signatures in breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Life Science-
dc.contributor.googleauthorKyeongmee Park-
dc.contributor.googleauthorJoo Hyun Lee-
dc.contributor.googleauthorHyun Ho Han-
dc.contributor.googleauthorSeong Gyeong Mun-
dc.contributor.googleauthorSuki Kang-
dc.contributor.googleauthorYoun Jin Cha-
dc.contributor.googleauthorJa-Seung Koo-
dc.contributor.googleauthorMin Ju Kim-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJieun Moon-
dc.contributor.googleauthorNam Hoon Cho-
dc.identifier.doi10.1016/j.prp.2016.11.017-
dc.contributor.localIdA00044-
dc.contributor.localIdA00198-
dc.contributor.localIdA03812-
dc.contributor.localIdA04001-
dc.relation.journalcodeJ02474-
dc.identifier.eissn1618-0631-
dc.identifier.pmid28476377-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0344033816304745-
dc.subject.keywordBreast cancer-
dc.subject.keywordERK-
dc.subject.keywordNode positive number-
dc.subject.keywordNode positive ratio-
dc.subject.keywordWDR1-
dc.subject.keywordc-MET-
dc.contributor.alternativeNameKang, Suki-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameCho, Nam Hoon-
dc.contributor.alternativeNameCha, Yoon Jin-
dc.contributor.affiliatedAuthorKang, Suki-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorCho, Nam Hoon-
dc.contributor.affiliatedAuthorCha, Yoon Jin-
dc.contributor.affiliatedAuthor구자승-
dc.citation.volume213-
dc.citation.number6-
dc.citation.startPage680-
dc.citation.endPage687-
dc.identifier.bibliographicCitationPathology Research and Practice, Vol.213(6) : 680-687, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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