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Immunological Prediction of Cytomegalovirus (CMV) Replication Risk in Solid Organ Transplantation Recipients: Approaches for Regulating the Targeted Anti-CMV Prevention Strategies

DC FieldValueLanguage
dc.contributor.author한상훈-
dc.date.accessioned2018-07-20T08:11:37Z-
dc.date.available2018-07-20T08:11:37Z-
dc.date.issued2017-
dc.identifier.issn2093-2340-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160943-
dc.description.abstractThe current cytomegalovirus (CMV) prevention strategies in solid organ transplantation (SOT) recipients have contributed towards overcoming the detrimental effects caused by CMV lytic infection, and improving the long-term success rate of graft survival. Although the quantification of CMV in peripheral blood is the standard method, and an excellent end-point for diagnosing CMV replication and modulating the anti-CMV prevention strategies in SOT recipients, a novel biomarker mimicking the CMV control mechanism is required. CMV-specific immune monitoring can be employed as a basic tool predicting CMV infection or disease after SOT, since uncontrolled CMV replication mostly originates from the impairment of immune responses against CMV under immunosuppressive conditions in SOT recipients. Several studies conducted during the past few decades have indicated the possibility of measuring the CMV-specific cell-mediated immune response in clinical situations. Among several analytical assays, the most advancing standardized tool is the QuantiFERON®-CMV assay. The T-Track® CMV kit that uses the standardized enzyme-linked immunospot assay is also widely employed. In addition to these assays, immunophenotyping and intracellular cytokine analysis using flow cytometry (with fluorescence-labeled monoclonal antibodies or peptide-major histocompatibility complex multimers) needs to be adequately standardized and validated for potential clinical applications.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean, English-
dc.publisher대한감염학회-
dc.relation.isPartOfINFECTION AND CHEMOTHERAPY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleImmunological Prediction of Cytomegalovirus (CMV) Replication Risk in Solid Organ Transplantation Recipients: Approaches for Regulating the Targeted Anti-CMV Prevention Strategies-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSang Hoon Han-
dc.identifier.doi10.3947/ic.2017.49.3.161-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ01053-
dc.identifier.eissn2092-6448-
dc.identifier.pmid29027383-
dc.subject.keywordCell-mediated immunity-
dc.subject.keywordCytomegalovirus-
dc.subject.keywordImmune monitoring-
dc.subject.keywordSolid organ transplantation-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.citation.volume49-
dc.citation.number3-
dc.citation.startPage161-
dc.citation.endPage175-
dc.identifier.bibliographicCitationINFECTION AND CHEMOTHERAPY, Vol.49(3) : 161-175, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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