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Effects of Triflusal and Clopidogrel on the Secondary Prevention of Stroke Based on Cytochrome P450 2C19 Genotyping

DC FieldValueLanguage
dc.contributor.author김윤남-
dc.contributor.author남효석-
dc.contributor.author이경아-
dc.contributor.author이경열-
dc.date.accessioned2018-07-20T08:10:06Z-
dc.date.available2018-07-20T08:10:06Z-
dc.date.issued2017-
dc.identifier.issn2287-6391-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160916-
dc.description.abstractBACKGROUND AND PURPOSE: To compare the efficacy and safety of antiplatelet agents for the secondary prevention of ischemic stroke based on cytochrome P450 2C19 (CYP2C19) polymorphisms. METHODS: This study was a prospective, multicenter, randomized, parallel-group, open-label, blind genotype trial. First time non-cardiogenic ischemic stroke patients were enrolled and screened within 30 days. Participants were randomized to receive either triflusal or clopidogrel for secondary stroke prevention. The primary outcome was the time from randomization to first recurrent ischemic stroke or hemorrhagic stroke. RESULTS: The required sample size was 1,080 but only 784 (73%) participants were recruited. In patients with a poor CYP2C19 genotype for clopidogrel metabolism (n=484), the risk of recurrent stroke among those who received triflusal treatment was 2.9% per year, which was not significantly different from those who received clopidogrel treatment (2.2% per year; hazard ratio [HR], 1.23; 95% confidence interval [CI], 0.60-2.53). In the clopidogrel treatment group (n=393), 38% had good genotypes and 62% poor genotypes for clopidogrel metabolism. The risk of recurrent stroke in patients with a good CYP2C19 genotype was 1.6% per year, which was not significantly different from those with a poor genotype (2.2% per year; HR, 0.69; 95% CI, 0.26-1.79). CONCLUSIONS: Whilst there were no significant differences between the treatment groups in the rates of stroke recurrence, major vascular events, or coronary revascularization, the efficacy of antiplatelet agents for the secondary prevention of stroke according to CYP2C19 genotype status remains unclear.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Stroke Society-
dc.relation.isPartOfJournal of Stroke-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleEffects of Triflusal and Clopidogrel on the Secondary Prevention of Stroke Based on Cytochrome P450 2C19 Genotyping-
dc.typeArticle-
dc.contributor.collegeOthers-
dc.contributor.departmentSeverance Hospital-
dc.contributor.googleauthorSang Won Han-
dc.contributor.googleauthorYong-Jae Kim-
dc.contributor.googleauthorSeong Hwan Ahn-
dc.contributor.googleauthorWoo-Keun Seo-
dc.contributor.googleauthorSungwook Yu-
dc.contributor.googleauthorSeung-Hun Oh-
dc.contributor.googleauthorHyo Suk Nam-
dc.contributor.googleauthorHye-Yeon Choi-
dc.contributor.googleauthorSung Sang Yoon-
dc.contributor.googleauthorSeo Hyun Kim-
dc.contributor.googleauthorJong Yun Lee-
dc.contributor.googleauthorJun Hong Lee-
dc.contributor.googleauthorYang-Ha Hwang-
dc.contributor.googleauthorKee Ook Lee-
dc.contributor.googleauthorYo Han Jung-
dc.contributor.googleauthorJun Lee-
dc.contributor.googleauthorSung-Il Sohn-
dc.contributor.googleauthorYoun Nam Kim-
dc.contributor.googleauthorKyung-A Lee-
dc.contributor.googleauthorCheryl D Bushnell-
dc.contributor.googleauthorKyung-Yul Lee-
dc.identifier.doi10.5853/jos.2017.01249-
dc.contributor.localIdA04535-
dc.contributor.localIdA01273-
dc.contributor.localIdA02647-
dc.contributor.localIdA02648-
dc.relation.journalcodeJ01758-
dc.identifier.eissn2287-6405-
dc.identifier.pmid29037010-
dc.subject.keywordClopidogrel-
dc.subject.keywordCytochrome P-450 CYP2C19-
dc.subject.keywordStroke-
dc.subject.keywordTriflusal-
dc.contributor.alternativeNameKim, Youn Nam-
dc.contributor.alternativeNameNam, Hyo Suk-
dc.contributor.alternativeNameLee, Kyung A-
dc.contributor.alternativeNameLee, Kyung Yul-
dc.contributor.affiliatedAuthorKim, Youn Nam-
dc.contributor.affiliatedAuthorNam, Hyo Suk-
dc.contributor.affiliatedAuthorLee, Kyung A-
dc.contributor.affiliatedAuthorLee, Kyung Yul-
dc.citation.volume19-
dc.citation.number3-
dc.citation.startPage356-
dc.citation.endPage364-
dc.identifier.bibliographicCitationJournal of Stroke, Vol.19(3) : 356-364, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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