Cited 43 times in
Effects of branched-chain amino acids (BCAAs) on the progression of advanced liver disease: A Korean nationwide, multicenter, retrospective, observational, cohort study
DC Field | Value | Language |
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dc.contributor.author | 김도영 | - |
dc.date.accessioned | 2018-07-20T08:08:04Z | - |
dc.date.available | 2018-07-20T08:08:04Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160862 | - |
dc.description.abstract | Evidence of the potential benefits of long-term oral branched-chain amino acid (BCAA) supplementation in reducing the severity of liver disease is limited.Patients who were diagnosed with liver cirrhosis with a Child-Pugh (CP) score of 8-10 were included. The BCAA group consumed BCAAs daily for at least 6 months, and the control group consumed a diet without BCAA. We analyzed the improvements based on the model for end-stage liver disease (MELD) score, CP score, incidence of cirrhosis-related complications, and event-free survival over 2 years. Among the 867 recruited patients, 307 (166 in the BCAA group and 141 in the control group) were analyzed. The BCAA group was divided into 3 subgroups, whose patients consumed 4.15 g, 8.3 g, or 12.45 g of BCAAs daily for the analysis. There were significant differences in the CP score, albumin, and hepatic encephalopathy between the 2 groups at baseline. After matching the propensity scores, we analyzed patients in the BCAA-12.45 g group (12.45 g of BCAAs daily, n = 41) and matched control group (n = 41). The MELD score significantly improved in the BCCA-12.45 g group compared to the matched control group (P = .004). The changes in the serum bilirubin level (P = .014) and CP score (P = .033) over time also differed significantly between the 2 groups. The incidence rates of cirrhosis-related complications (P = .973) and development of hepatocellular carcinoma (2 cases each) did not differ significantly between the 2 groups.Long-term oral BCAA supplementation has beneficial effects in patients with advanced liver cirrhosis. A further large-scale prospective study is needed to delineate these beneficial effects. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effects of branched-chain amino acids (BCAAs) on the progression of advanced liver disease: A Korean nationwide, multicenter, retrospective, observational, cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Jung Gil Park | - |
dc.contributor.googleauthor | Won Young Tak | - |
dc.contributor.googleauthor | Soo Young Park | - |
dc.contributor.googleauthor | Young Oh Kweon | - |
dc.contributor.googleauthor | Se Young Jang | - |
dc.contributor.googleauthor | Yu Rim Lee | - |
dc.contributor.googleauthor | Si Hyun Bae | - |
dc.contributor.googleauthor | Jae Young Jang | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | June Sung Lee | - |
dc.contributor.googleauthor | Ki Tae Suk | - |
dc.contributor.googleauthor | In Hee Kim | - |
dc.contributor.googleauthor | Heon Ju Lee | - |
dc.contributor.googleauthor | Woo Jin Chung | - |
dc.contributor.googleauthor | Byoung Kuk Jang | - |
dc.contributor.googleauthor | Jeong Ill Suh | - |
dc.contributor.googleauthor | Jeong Heo | - |
dc.contributor.googleauthor | Won Kee Lee | - |
dc.identifier.doi | 10.1097/MD.0000000000006580 | - |
dc.contributor.localId | A00385 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 28614215 | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.citation.volume | 96 | - |
dc.citation.number | 24 | - |
dc.citation.startPage | e6580 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.96(24) : e6580, 2017 | - |
dc.identifier.rimsid | 60746 | - |
dc.type.rims | ART | - |
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