Cited 45 times in
Impact of atrial fibrillation on the clinical course of apical hypertrophic cardiomyopathy
DC Field | Value | Language |
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dc.contributor.author | 김종윤 | - |
dc.contributor.author | 박희남 | - |
dc.contributor.author | 엄재선 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 정보영 | - |
dc.contributor.author | 이상은 | - |
dc.date.accessioned | 2018-07-20T08:04:05Z | - |
dc.date.available | 2018-07-20T08:04:05Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1355-6037 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160809 | - |
dc.description.abstract | BACKGROUND: Apical hypertrophic cardiomyopathy (ApHCM) is considered a 'benign' form of hypertrophic cardiomyopathy, with limited data on the long-term outcome. However, the clinical impact of atrial fibrillation (AF) in ApHCM is largely unknown. The hypothesis was that AF is common and has a prognostic implication in ApHCM. METHODS: The occurrence of AF and outcome was assessed in 306 consecutive patients with ApHCM (68% male, 62±11 years). RESULTS: AF occurred in 77 patients with ApHCM (prevalence, 25.2%; annual incidence, 4.6%/year) and was independently predicted by old age and large left atrium (>45 mm). Among 70 AF patients indicated with anticoagulation, 53 patients (76%) received warfarin. During a follow-up of 5.5±2.0 years, the patients with AF had a higher incidence of all-cause death, cardiovascular death and strokes (11.7% vs 1.3%, 6.5% vs 0.9% and 19.5% vs 2.6%, respectively, all p<0.05) than those without AF. When adjusted by the age and gender, those with AF still had an increased risk for all-cause death (HR 6.58; 95% CI 1.65-26.16, p=0.007) and strokes (HR 5.13; 95% CI 1.85 to 14.18, p=0.002). AF was detected before the time of stroke in 8 (53%) out of 15 patients with both AF and stroke. In addition, six out of eight patients were on anticoagulation at the time of stroke. The cause of death was a stroke in three (33%) out of nine patients with AF. CONCLUSION: In patients with ApHCM, AF was common and was associated with a substantial risk for strokes and mortality suggesting that AF should be carefully managed in ApHCM. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | BMJ Pub. Group. | - |
dc.relation.isPartOf | HEART | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Atrial Fibrillation/epidemiology | - |
dc.subject.MESH | Atrial Fibrillation/etiology* | - |
dc.subject.MESH | Atrial Fibrillation/physiopathology | - |
dc.subject.MESH | Cardiomyopathy, Hypertrophic/complications* | - |
dc.subject.MESH | Cardiomyopathy, Hypertrophic/diagnosis | - |
dc.subject.MESH | Cardiomyopathy Hypertrophic/epidemiology | - |
dc.subject.MESH | Cause of Death/trends | - |
dc.subject.MESH | Echocardiography | - |
dc.subject.MESH | Electrocardiography | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Heart Atria/diagnostic imaging | - |
dc.subject.MESH | Heart Atria/physiopathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Survival Rate/trends | - |
dc.title | Impact of atrial fibrillation on the clinical course of apical hypertrophic cardiomyopathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Sang-Eun Lee | - |
dc.contributor.googleauthor | Jin-Kyu Park | - |
dc.contributor.googleauthor | Jae-Sun Uhm | - |
dc.contributor.googleauthor | Jong Youn Kim | - |
dc.contributor.googleauthor | Hui-Nam Pak | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Boyoung Joung | - |
dc.identifier.doi | 10.1136/heartjnl-2016-310720 | - |
dc.contributor.localId | A00926 | - |
dc.contributor.localId | A01776 | - |
dc.contributor.localId | A02337 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A03609 | - |
dc.relation.journalcode | J00976 | - |
dc.identifier.eissn | 1468-201X | - |
dc.identifier.pmid | 28428444 | - |
dc.identifier.url | http://heart.bmj.com/content/103/19/1496.long | - |
dc.subject.keyword | apical hypertrophic cardiomyopathy | - |
dc.subject.keyword | atrial fibrillation | - |
dc.subject.keyword | stroke | - |
dc.contributor.alternativeName | Kim, Jong Youn | - |
dc.contributor.alternativeName | Pak, Hui Nam | - |
dc.contributor.alternativeName | Uhm, Jae Sun | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.alternativeName | Joung, Bo Young | - |
dc.contributor.affiliatedAuthor | Kim, Jong Youn | - |
dc.contributor.affiliatedAuthor | Pak, Hui Nam | - |
dc.contributor.affiliatedAuthor | Uhm, Jae Sun | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Joung, Bo Young | - |
dc.citation.volume | 103 | - |
dc.citation.number | 19 | - |
dc.citation.startPage | 1496 | - |
dc.citation.endPage | 1501 | - |
dc.identifier.bibliographicCitation | HEART, Vol.103(19) : 1496-1501, 2017 | - |
dc.identifier.rimsid | 60693 | - |
dc.type.rims | ART | - |
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