Cited 0 times in
Bile Acid Receptor Farnesoid X Receptor: A Novel Therapeutic Target for Metabolic Diseases
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 황성순 | - |
dc.date.accessioned | 2018-07-20T08:03:51Z | - |
dc.date.available | 2018-07-20T08:03:51Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 2287-2892 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160803 | - |
dc.description.abstract | Bile acid has been well known to serve as a hormone in regulating transcriptional activity of Farnesoid X receptor (FXR), an endogenous bile acid nuclear receptor. Moreover, bile acid regulates diverse biological processes, including cholesterol/bile acid metabolism, glucose/lipid metabolism and energy expenditure. Alteration of bile acid metabolism has been revealed in type II diabetic (T2D) patients. FXR-mediated bile acid signaling has been reported to play key roles in improving metabolic parameters in vertical sleeve gastrectomy surgery, implying that FXR is an essential modulator in the metabolic homeostasis. Using a genetic mouse model, intestinal specific FXR-null mice have been reported to be resistant to diet-induced obesity and insulin resistance. Moreover, intestinal specific FXR agonism using gut-specific FXR synthetic agonist has been shown to enhance thermogenesis in brown adipose tissue and browning in white adipose tissue to increase energy expenditure, leading to reduced body weight gain and improved insulin resistance. Altogether, FXR is a potent therapeutic target for the treatment of metabolic diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 한국지질동맥경화학회 | - |
dc.relation.isPartOf | Journal of Lipid and Atherosclerosis | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Bile Acid Receptor Farnesoid X Receptor: A Novel Therapeutic Target for Metabolic Diseases | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | Sungsoon Fang | - |
dc.identifier.doi | 10.12997/jla.2017.6.1.1 | - |
dc.contributor.localId | A05443 | - |
dc.relation.journalcode | J01562 | - |
dc.identifier.eissn | 2288-2561 | - |
dc.subject.keyword | Bile acids | - |
dc.subject.keyword | Farnesoid X receptor | - |
dc.subject.keyword | Metabolic diseases | - |
dc.contributor.alternativeName | Fang, Sungsoon | - |
dc.contributor.affiliatedAuthor | Fang, Sungsoon | - |
dc.citation.volume | 6 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.identifier.bibliographicCitation | Journal of Lipid and Atherosclerosis, Vol.6(1) : 1-7, 2017 | - |
dc.identifier.rimsid | 60687 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.