Cited 5 times in

Fever as an initial manifestation of spondyloarthritis: A retrospective study.

DC Field Value Language
dc.contributor.author박용범-
dc.contributor.author변세진-
dc.contributor.author송정식-
dc.contributor.author이상원-
dc.contributor.author정승민-
dc.date.accessioned2018-07-20T08:02:05Z-
dc.date.available2018-07-20T08:02:05Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160776-
dc.description.abstractOBJECTIVES: We aimed to evaluate a wide spectrum of clinical features of adult patients with spondyloarthritis (SpA) whose initial manifestation was fever, using the Assessment of SpondyloArthritis international Society (ASAS) classification criteria. METHODS: We retrospectively collected the electronic medical records of hospitalized SpA patients who initially presented to the Severance Hospital (Seoul, Korea) with fever from January 2010 to May 2016. As a control group, we also recruited one-hundred consecutive patients who were diagnosed with SpA in our outpatient clinic. Clinical features and laboratory findings were compared in two patient groups. RESULTS: There were 26 patients who had fever as initial presentation of SpA (reactive arthritis 50%, undifferentiated SpA 26.9%, ankylosing spondylitis 15.4%, enteropathic arthritis 3.8%, psoriatic arthritis 3.8%). Peripheral SpA was more common in febrile SpA patients than in control SpA patients (65.4% vs 24.0%, p<0.001). Febrile SpA patients were less frequently HLA-B27 positive than control SpA patients (52.2% vs 77.0%, p<0.05). At baseline, systemic inflammatory markers were significantly higher in the febrile SpA patients (white blood cell count, 11.57 vs 7.81 cells/μL, p<0.001; erythrocyte sedimentation rate, 69.2 vs 41.0 mm/h, p<0.001; C-reactive protein, 109.6 vs 15.3 mg/L, p<0.001). The proportion of patients treated with systemic steroids was significantly higher in febrile SpA patients (57.7% vs. 11.0%, p<0.001). The proportion of patients who visited rheumatology specialty was significantly lower in febrile SpA patients than in control SpA patients (7.7% vs 59.0%, p<0.001). CONCLUSION: Various subgroups of SpA can be presented with fever as an initial manifestation. Febrile SpA patients demonstrated higher systemic inflammation and a lower chance to visit rheumatology in early stage. When evaluating febrile patients with any clinical features of SpA, clinicians are advised to consider performing SpA-focused evaluation including HLA-B27 or a simple sacroiliac joint radiograph.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAnti-Inflammatory Agents, Non-Steroidal/therapeutic use-
dc.subject.MESHBiomarkers/analysis-
dc.subject.MESHElectronic Health Records-
dc.subject.MESHFemale-
dc.subject.MESHFever/epidemiology-
dc.subject.MESHFever/etiology-
dc.subject.MESHFever/immunology-
dc.subject.MESHHLA-B7 Antigen/metabolism-
dc.subject.MESHHospitalization/statistics & numerical data-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSpondylarthritis/classification-
dc.subject.MESHSpondylarthritis/drug therapy-
dc.subject.MESHSpondylarthritis/immunology-
dc.subject.MESHSteroids/standards-
dc.subject.MESHTreatment Outcome-
dc.titleFever as an initial manifestation of spondyloarthritis: A retrospective study.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSe Jin Byun-
dc.contributor.googleauthorWilliam Han Bae-
dc.contributor.googleauthorseung Min Jung-
dc.contributor.googleauthorSang-Won Lee-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorJason Jungsik Song-
dc.identifier.doi10.1371/journal.pone.0184323-
dc.contributor.localIdA01579-
dc.contributor.localIdA04953-
dc.contributor.localIdA02057-
dc.contributor.localIdA02824-
dc.contributor.localIdA05179-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid28910361-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNameByun, Se Jin-
dc.contributor.alternativeNameSong, Jung Sik-
dc.contributor.alternativeNameLee, Sang Won-
dc.contributor.alternativeNameJung, SeungMin-
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.contributor.affiliatedAuthorByun, Se Jin-
dc.contributor.affiliatedAuthorSong, Jung Sik-
dc.contributor.affiliatedAuthorLee, Sang Won-
dc.contributor.affiliatedAuthorJung, SeungMin-
dc.citation.volume12-
dc.citation.number9-
dc.citation.startPagee0184323-
dc.identifier.bibliographicCitationPLOS ONE, Vol.12(9) : e0184323, 2017-
dc.identifier.rimsid60662-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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