Cited 5 times in
Fever as an initial manifestation of spondyloarthritis: A retrospective study.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박용범 | - |
dc.contributor.author | 변세진 | - |
dc.contributor.author | 송정식 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 정승민 | - |
dc.date.accessioned | 2018-07-20T08:02:05Z | - |
dc.date.available | 2018-07-20T08:02:05Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160776 | - |
dc.description.abstract | OBJECTIVES: We aimed to evaluate a wide spectrum of clinical features of adult patients with spondyloarthritis (SpA) whose initial manifestation was fever, using the Assessment of SpondyloArthritis international Society (ASAS) classification criteria. METHODS: We retrospectively collected the electronic medical records of hospitalized SpA patients who initially presented to the Severance Hospital (Seoul, Korea) with fever from January 2010 to May 2016. As a control group, we also recruited one-hundred consecutive patients who were diagnosed with SpA in our outpatient clinic. Clinical features and laboratory findings were compared in two patient groups. RESULTS: There were 26 patients who had fever as initial presentation of SpA (reactive arthritis 50%, undifferentiated SpA 26.9%, ankylosing spondylitis 15.4%, enteropathic arthritis 3.8%, psoriatic arthritis 3.8%). Peripheral SpA was more common in febrile SpA patients than in control SpA patients (65.4% vs 24.0%, p<0.001). Febrile SpA patients were less frequently HLA-B27 positive than control SpA patients (52.2% vs 77.0%, p<0.05). At baseline, systemic inflammatory markers were significantly higher in the febrile SpA patients (white blood cell count, 11.57 vs 7.81 cells/μL, p<0.001; erythrocyte sedimentation rate, 69.2 vs 41.0 mm/h, p<0.001; C-reactive protein, 109.6 vs 15.3 mg/L, p<0.001). The proportion of patients treated with systemic steroids was significantly higher in febrile SpA patients (57.7% vs. 11.0%, p<0.001). The proportion of patients who visited rheumatology specialty was significantly lower in febrile SpA patients than in control SpA patients (7.7% vs 59.0%, p<0.001). CONCLUSION: Various subgroups of SpA can be presented with fever as an initial manifestation. Febrile SpA patients demonstrated higher systemic inflammation and a lower chance to visit rheumatology in early stage. When evaluating febrile patients with any clinical features of SpA, clinicians are advised to consider performing SpA-focused evaluation including HLA-B27 or a simple sacroiliac joint radiograph. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Anti-Inflammatory Agents, Non-Steroidal/therapeutic use | - |
dc.subject.MESH | Biomarkers/analysis | - |
dc.subject.MESH | Electronic Health Records | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fever/epidemiology | - |
dc.subject.MESH | Fever/etiology | - |
dc.subject.MESH | Fever/immunology | - |
dc.subject.MESH | HLA-B7 Antigen/metabolism | - |
dc.subject.MESH | Hospitalization/statistics & numerical data | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Spondylarthritis/classification | - |
dc.subject.MESH | Spondylarthritis/drug therapy | - |
dc.subject.MESH | Spondylarthritis/immunology | - |
dc.subject.MESH | Steroids/standards | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Fever as an initial manifestation of spondyloarthritis: A retrospective study. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Se Jin Byun | - |
dc.contributor.googleauthor | William Han Bae | - |
dc.contributor.googleauthor | seung Min Jung | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Jason Jungsik Song | - |
dc.identifier.doi | 10.1371/journal.pone.0184323 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A04953 | - |
dc.contributor.localId | A02057 | - |
dc.contributor.localId | A02824 | - |
dc.contributor.localId | A05179 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 28910361 | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Byun, Se Jin | - |
dc.contributor.alternativeName | Song, Jung Sik | - |
dc.contributor.alternativeName | Lee, Sang Won | - |
dc.contributor.alternativeName | Jung, SeungMin | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Byun, Se Jin | - |
dc.contributor.affiliatedAuthor | Song, Jung Sik | - |
dc.contributor.affiliatedAuthor | Lee, Sang Won | - |
dc.contributor.affiliatedAuthor | Jung, SeungMin | - |
dc.citation.volume | 12 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | e0184323 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.12(9) : e0184323, 2017 | - |
dc.identifier.rimsid | 60662 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.