Cited 30 times in
Outcomes of Treatment for Malignant Peripheral Nerve Sheath Tumors: Different Clinical Features Associated with Neurofibromatosis Type 1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김상겸 | - |
dc.contributor.author | 김효선 | - |
dc.contributor.author | 김효송 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 신규호 | - |
dc.contributor.author | 유철주 | - |
dc.contributor.author | 한승민 | - |
dc.contributor.author | 한정우 | - |
dc.contributor.author | 황인경 | - |
dc.date.accessioned | 2018-07-20T08:00:57Z | - |
dc.date.available | 2018-07-20T08:00:57Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160759 | - |
dc.description.abstract | PURPOSE: Malignant peripheral nerve sheath tumors (MPNSTs) are a rare subtype of sarcoma that occur spontaneously or in association with neurofibromatosis type 1 (NF-1). This study aimed to clinically differentiate these types of MPNSTs. MATERIALS AND METHODS: The study reviewed 95 patients diagnosed with and treated for MPNST at Yonsei University Health System, Seoul, Korea over a 27-year period. The clinical characteristics, prognostic factors, and treatment outcomes of sporadic MPNST (sMPNST) and NF-1 associated MPNST (NF-MPNST) cases were compared. RESULTS: Patients with NF-MPNST had a significantly lower median age (32 years vs. 45 years for sMPNST, p=0.012), significantly larger median tumor size (8.2 cm vs. 5.0 cm for sMPNST, p < 0.001), and significantly larger numbers of imaging studies and surgeries (p=0.004 and p < 0.001, respectively). The 10-year overall survival (OS) rate of the patients with MPNST was 52±6%. Among the patients with localized MPNST, patients with NF-MPNST had a significantly lower 10-year OS rate (45±11% vs. 60±8% for sMPNST, p=0.046). Univariate analysis revealed the resection margin, pathology grade, and metastasis to be significant factors affecting the OS (p=0.001, p=0.020, and p < 0.001, respectively). Multivariate analysis of the patients with localized MPNST identified R2 resection and G1 as significant prognostic factors for OS. CONCLUSION: NF-MPNST has different clinical features from sMPNST and requires more careful management. Further study will be needed to develop specific management plans for NF-MPNST. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Biopsy | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Combined Modality Therapy/adverse effects | - |
dc.subject.MESH | Combined Modality Therapy/methods | - |
dc.subject.MESH | Disease Management | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Neurofibromatosis 1/diagnosis | - |
dc.subject.MESH | Neurofibromatosis 1/mortality* | - |
dc.subject.MESH | Neurofibromatosis 1/therapy* | - |
dc.subject.MESH | Peripheral Nervous System Neoplasms/diagnosis | - |
dc.subject.MESH | Peripheral Nervous System | - |
dc.subject.MESH | Neoplasms/mortality* | - |
dc.subject.MESH | Peripheral Nervous System Neoplasms/therapy* | - |
dc.subject.MESH | Practice Patterns, Physicians' | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Treatment Outcome | - |
dc.subject.MESH | Tumor Burden | - |
dc.subject.MESH | Young Adult | - |
dc.title | Outcomes of Treatment for Malignant Peripheral Nerve Sheath Tumors: Different Clinical Features Associated with Neurofibromatosis Type 1 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | n Kyung Hwang | - |
dc.contributor.googleauthor | Seung Min Hahn | - |
dc.contributor.googleauthor | Hyo Sun Kim | - |
dc.contributor.googleauthor | Sang Kyum Kim | - |
dc.contributor.googleauthor | Hyo Song Kim | - |
dc.contributor.googleauthor | Kyoo-Ho Shin | - |
dc.contributor.googleauthor | Chang Ok Suh | - |
dc.contributor.googleauthor | Chuhl Joo Lyu | - |
dc.contributor.googleauthor | Jung Woo Han | - |
dc.identifier.doi | 10.4143/crt.2016.271 | - |
dc.contributor.localId | A00520 | - |
dc.contributor.localId | A01201 | - |
dc.contributor.localId | A01202 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A02086 | - |
dc.contributor.localId | A02524 | - |
dc.contributor.localId | A04299 | - |
dc.contributor.localId | A04325 | - |
dc.contributor.localId | A05444 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 28052660 | - |
dc.subject.keyword | Neoplasms | - |
dc.subject.keyword | Neurilemmoma | - |
dc.subject.keyword | Neurofibromatoses | - |
dc.subject.keyword | Sarcoma | - |
dc.contributor.alternativeName | Kim, Sang Kyum | - |
dc.contributor.alternativeName | Kim, Hyo Sun | - |
dc.contributor.alternativeName | Kim, Hyo Song | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Shin, Kyoo Ho | - |
dc.contributor.alternativeName | Lyu, Chuhl Joo | - |
dc.contributor.alternativeName | Hahn, Seung Min | - |
dc.contributor.alternativeName | Han, Jung Woo | - |
dc.contributor.alternativeName | Hwang, In Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Sang Kyum | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Sun | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Song | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Shin, Kyoo Ho | - |
dc.contributor.affiliatedAuthor | Lyu, Chuhl Joo | - |
dc.contributor.affiliatedAuthor | Hahn, Seung Min | - |
dc.contributor.affiliatedAuthor | Han, Jung Woo | - |
dc.contributor.affiliatedAuthor | Hwang, In Kyung | - |
dc.citation.volume | 49 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 717 | - |
dc.citation.endPage | 726 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.49(3) : 717-726, 2017 | - |
dc.identifier.rimsid | 60645 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.