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Effects of dexmedetomidine in combination with fentanyl-based intravenous patient-controlled analgesia on pain attenuation after open gastrectomy in comparison with conventional thoracic epidural and fentanyl-based intravenous patient-controlled analgesia

DC FieldValueLanguage
dc.contributor.author권태동-
dc.contributor.author김나영-
dc.contributor.author노성훈-
dc.contributor.author배일권-
dc.contributor.author이기영-
dc.contributor.author이해연-
dc.date.accessioned2018-07-20T07:57:15Z-
dc.date.available2018-07-20T07:57:15Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160703-
dc.description.abstractBackground: This study was investigated the effects of dexmedetomidine in combination with fentanyl-based intravenous patient-controlled analgesia (IV-PCA) on pain attenuation in patients undergoing open gastrectomy in comparison with conventional thoracic epidural patient-controlled analgesia (E-PCA) and IV-PCA. Methods: One hundred seventy-one patients who planned open gastrectomy were randomly distributed into one of the 3 groups: conventional thoracic E-PCA (E-PCA group, n = 57), dexmedetomidine in combination with fentanyl-based IV-PCA (dIV-PCA group, n = 57), or fentanyl-based IV-PCA only (IV-PCA group, n = 57). The primary outcome was the postoperative pain intensity (numerical rating scale) at 3 hours after surgery, and the secondary outcomes were the number of bolus deliveries and bolus attempts, and the number of patients who required additional rescue analgesics. Mean blood pressure, heart rate, and adverse effects were evaluated as well. Results: One hundred fifty-three patients were finally completed the study. The postoperative pain intensity was significantly lower in the dIV-PCA and E-PCA groups than in the IV-PCA group, but comparable between the dIV-PCA group and the E-PCA group. Patients in the dIV-PCA and E-PCA groups needed significantly fewer additional analgesic rescues between 6 and 24 hours after surgery, and had a significantly lower number of bolus attempts and bolus deliveries during the first 24 hours after surgery than those in the IV-PCA group. Conclusions: Dexmedetomidine in combination with fentanyl-based IV-PCA significantly improved postoperative analgesia in patients undergoing open gastrectomy without hemodynamic instability, which was comparable to thoracic E-PCA. Furthermore, this approach could be clinically more meaningful owing to its noninvasive nature.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherIvyspring International Publisher-
dc.relation.isPartOfInternational Journal of Medical Sciences-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdministration, Intravenous-
dc.subject.MESHAdrenergic alpha-2 Receptor Agonists/therapeutic use*-
dc.subject.MESHAged-
dc.subject.MESHAnalgesia, Epidural/methods-
dc.subject.MESHAnalgesia, Patient-Controlled/methods-
dc.subject.MESHAnalgesics, Opioid/therapeutic use*-
dc.subject.MESHDexmedetomidine/administration & dosage-
dc.subject.MESHDexmedetomidine/therapeutic use*-
dc.subject.MESHDrug Therapy, Combination/methods-
dc.subject.MESHFemale-
dc.subject.MESHFentanyl/therapeutic use*-
dc.subject.MESHGastrectomy/adverse effects*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPain Management/methods-
dc.subject.MESHPain Measurement-
dc.subject.MESHPain, Postoperative/drug therapy*-
dc.subject.MESHPain, Postoperative/etiology-
dc.subject.MESHProspective Studies-
dc.titleEffects of dexmedetomidine in combination with fentanyl-based intravenous patient-controlled analgesia on pain attenuation after open gastrectomy in comparison with conventional thoracic epidural and fentanyl-based intravenous patient-controlled analgesia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine-
dc.contributor.googleauthorNa Young Kim-
dc.contributor.googleauthorTae Dong Kwon-
dc.contributor.googleauthorSun Joon Bai-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorJung Hwa Hong-
dc.contributor.googleauthorHaeyeon Lee-
dc.contributor.googleauthorKi-Young Lee-
dc.identifier.doi10.7150/ijms.20347-
dc.contributor.localIdA00255-
dc.contributor.localIdA00348-
dc.contributor.localIdA01281-
dc.contributor.localIdA01802-
dc.contributor.localIdA02695-
dc.contributor.localIdA05391-
dc.relation.journalcodeJ02917-
dc.identifier.eissn1449-1907-
dc.identifier.pmid28924366-
dc.subject.keyworddexmedetomidine-
dc.subject.keywordepidural-
dc.subject.keywordfentanyl-
dc.subject.keywordintravenous-
dc.subject.keywordpatient-controlled analgesia-
dc.subject.keywordpostoperative pain-
dc.contributor.alternativeNameKweon, Tae Dong-
dc.contributor.alternativeNameKim, Na Young-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameBae, Il Kwon-
dc.contributor.alternativeNameLee, Ki Young-
dc.contributor.alternativeNameLee, Haeyeon-
dc.contributor.affiliatedAuthorKweon, Tae Dong-
dc.contributor.affiliatedAuthorKim, Na Young-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorBae, Il Kwon-
dc.contributor.affiliatedAuthorLee, Ki Young-
dc.contributor.affiliatedAuthorLee, Haeyeon-
dc.citation.volume14-
dc.citation.number10-
dc.citation.startPage951-
dc.citation.endPage960-
dc.identifier.bibliographicCitationInternational Journal of Medical Sciences, Vol.14(10) : 951-960, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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