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Decreased ex vivo production of interferon-gamma is associated with severity and poor prognosis in patients with lupus
DC Field | Value | Language |
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dc.contributor.author | 김범석 | - |
dc.contributor.author | 박용범 | - |
dc.contributor.author | 박은성 | - |
dc.contributor.author | 송정식 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 정승민 | - |
dc.date.accessioned | 2018-07-20T07:54:55Z | - |
dc.date.available | 2018-07-20T07:54:55Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1478-6354 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160662 | - |
dc.description.abstract | BACKGROUND: Lupus pathogenesis is closely associated with interferon gamma (IFN-γ), which plays a central role in innate and adaptive immunity. The aim of this study was to evaluate the ex vivo production of IFN-γ after stimulation of peripheral blood mononuclear cells with phytohemagglutinin (PHA) in patients with lupus, according to disease activity. METHODS: This study included 118 patients with lupus who had undergone IFN-γ-releasing assays (IGRAs) to screen for tuberculosis. Data on IFN-γ production in negative (nil) and positive (mitogen with PHA) controls were collected and analysed. The difference (mitogen minus nil) was used to calculate ex vivo IFN-γ production. Disease activity was evaluated using the Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2 K). Poor hospitalisation outcome was defined as in-hospital mortality or intensive care unit admission. Associations among disease activity, poor hospitalisation outcome, and ex vivo IFN-γ production were assessed. RESULTS: The level of ex vivo IFN-γ production was significantly lower in patients with active systemic lupus erythematosus (SLE) (n = 64) than in those with inactive SLE (n = 54) (median 0.92 vs. 11.06 IU/mL, p < 0.001). Ex vivo IFN-γ production was correlated with the SLEDAI-2 K (r = - 0.587, p < 0.001). Results of multivariate logistic regression analysis showed that ex vivo IFN-γ production ≤ 7.19 IU/mL was an independent predictor for discriminating active and inactive lupus. In addition, patients with ex vivo IFN-γ production ≤ 0.40 IU/mL had more frequent poor hospitalisation outcomes than those with ex vivo IFN-γ production > 0.40 (40.0% vs. 9.3%, p = 0.001). The proportion of indeterminate IGRA results was higher in patients with active lupus than in those with inactive lupus (45.3% vs. 0.0%, p < 0.001) because of decreased ex vivo IFN-γ production. CONCLUSIONS: Ex vivo IFN-γ production is a useful biomarker for assessing disease activity and predicting poor clinical outcomes of SLE. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | ARTHRITIS RESEARCH & THERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Decreased ex vivo production of interferon-gamma is associated with severity and poor prognosis in patients with lupus | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Sung Soo Ahn | - |
dc.contributor.googleauthor | Eun Seong Park | - |
dc.contributor.googleauthor | Joo Sung Shim | - |
dc.contributor.googleauthor | Sang-Jun Ha | - |
dc.contributor.googleauthor | Beom Seok Kim | - |
dc.contributor.googleauthor | Seung Min Jung | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Jason Jungsik Song | - |
dc.identifier.doi | 10.1186/s13075-017-1404-z | - |
dc.contributor.localId | A00488 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A05128 | - |
dc.contributor.localId | A02057 | - |
dc.contributor.localId | A02233 | - |
dc.contributor.localId | A02824 | - |
dc.contributor.localId | A05179 | - |
dc.relation.journalcode | J00241 | - |
dc.identifier.eissn | 1478-6362 | - |
dc.identifier.pmid | 28841837 | - |
dc.subject.keyword | IFN-γ | - |
dc.subject.keyword | IFN-γ releasing assay | - |
dc.subject.keyword | Systemic lupus erythematosus | - |
dc.subject.keyword | T cell | - |
dc.contributor.alternativeName | Kim, Beom Seok | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Park, EunSeong | - |
dc.contributor.alternativeName | Song, Jung Sik | - |
dc.contributor.alternativeName | Ahn, Sung Soo | - |
dc.contributor.alternativeName | Lee, Sang Won | - |
dc.contributor.alternativeName | Jung, SeungMin | - |
dc.contributor.affiliatedAuthor | Kim, Beom Seok | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Park, EunSeong | - |
dc.contributor.affiliatedAuthor | Song, Jung Sik | - |
dc.contributor.affiliatedAuthor | Ahn, Sung Soo | - |
dc.contributor.affiliatedAuthor | Lee, Sang Won | - |
dc.contributor.affiliatedAuthor | Jung, SeungMin | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 193 | - |
dc.identifier.bibliographicCitation | ARTHRITIS RESEARCH & THERAPY, Vol.19(1) : 193, 2017 | - |
dc.identifier.rimsid | 41834 | - |
dc.type.rims | ART | - |
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