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Prenatal exposure to dexamethasone in the mouse induces sex-specific differences in placental gene expression

Authors
 Ji‐Yeon Lee  ;  Hyo Jung Yun  ;  Clara Yuri Kim  ;  Yong Woo Cho  ;  Yongmin Lee  ;  Myoung Hee Kim 
Citation
 DEVELOPMENT GROWTH & DIFFERENTIATION, Vol.59(6) : 515-525, 2017 
Journal Title
DEVELOPMENT GROWTH & DIFFERENTIATION
ISSN
 0012-1592 
Issue Date
2017
Keywords
RNA-Seq ; dexamethasone ; placenta ; sex-specific
Abstract
Prenatal stress during pregnancy leads to sex-specific effects on fetal development and disease susceptibility over the life span; however, the origin of sex differences has not been identified. The placenta not only plays a key role in fetal growth and development throughout pregnancy, but also affects the fetal programming underlying subsequent adult health and accounts. Therefore, sex-specific adaptation of the placenta may be central to the sex differences in fetal growth and survival. Here, we analyzed the effects of prenatal dexamethasone (Dex) on sex-specific changes in placental gene expression using RNA-Seq. Placental tissues from males and females were separated into two developmentally distinct fetal and maternal parts at E11.5 stage. The majority of genes in female placentas were downregulated by prenatal Dex, whereas those were mostly maintained or rather upregulated in male placentas. RNA-Seq results were validated using independent biological replicates from the same stage and placental tissue samples from E18.5 by realtime PCR assays. Activation of various inflammatory response-related genes, chemokines and their receptors, particularly in male placentas, strongly implies that prenatal Dex exposure causes sex-specific physiological responses that can lead to inflammatory diseases involving vascular pathology.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/dgd.12376
DOI
10.1111/dgd.12376
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Myoung Hee(김명희) ORCID logo https://orcid.org/0000-0001-5652-1452
Lee, Ji Yeon(이지연) ORCID logo https://orcid.org/0000-0002-0670-3095
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160646
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