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An indirect method for in vivo T2 mapping of [1-13 C] pyruvate using hyperpolarized 13 C CSI.

Authors
 Eunhae Joe  ;  Hansol Lee  ;  Joonsung Lee  ;  Seungwook Yang  ;  Young‐Suk Choi  ;  Eunkyung Wang  ;  Ho‐Taek Song  ;  Dong‐Hyun Kim 
Citation
 NMR IN BIOMEDICINE, Vol.30(5) : e3690, 2017 
Journal Title
 NMR IN BIOMEDICINE 
ISSN
 0952-3480 
Issue Date
2017
MeSH
Algorithms ; Animals ; Biomarkers, Tumor/metabolism ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Carbon-13 Magnetic Resonance Spectroscopy/methods ; Female ; Glioma/metabolism ; Glioma/pathology ; Pyruvic Acid/metabolism ; Rats ; Rats, Sprague-Dawley ; Reproducibility of Results ; Sensitivity and Specificity ; Signal Processing, Computer-Assisted ; Tissue Distribution
Keywords
C6 glioma ; T2 relaxation time ; [1-13C] pyruvate ; hyperpolarized 13C ; in vivo metabolic CSI
Abstract
An indirect method for in vivo T2 mapping of 13 C-labeled metabolites using T2 and T2 * information of water protons obtained a priori is proposed. The T2 values of 13 C metabolites are inferred using the relationship to T2 ' of coexisting 1 H and the T2 * of 13 C metabolites, which is measured using routine hyperpolarized 13 C CSI data. The concept is verified with phantom studies. Simulations were performed to evaluate the extent of T2 estimation accuracy due to errors in the other measurements. Also, bias in the 13 C T2 * estimation from the 13 C CSI data was studied. In vivo experiments were performed from the brains of normal rats and a rat with C6 glioma. Simulation results indicate that the proposed method provides accurate and unbiased 13 C T2 values within typical experimental settings. The in vivo studies found that the estimated T2 of [1-13 C] pyruvate using the indirect method was longer in tumor than in normal tissues and gave values similar to previous reports. This method can estimate localized T2 relaxation times from multiple voxels using conventional hyperpolarized 13 C CSI and can potentially be used with time resolved fast CSI.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/nbm.3690
DOI
10.1002/nbm.3690
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Song, Ho Taek(송호택) ORCID logo https://orcid.org/0000-0002-6655-2575
Choi, Young Suk(최영숙) ORCID logo https://orcid.org/0000-0003-4930-8455
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160641
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