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Effects of Neutralization by Soluble ABH Antigens Produced by Transplanted Kidneys From ABO-Incompatible Secretor Donors

DC FieldValueLanguage
dc.contributor.author김명수-
dc.contributor.author김신영-
dc.contributor.author김유선-
dc.contributor.author김지은-
dc.contributor.author김현옥-
dc.contributor.author이재근-
dc.contributor.author최종락-
dc.date.accessioned2018-07-20T07:53:08Z-
dc.date.available2018-07-20T07:53:08Z-
dc.date.issued2017-
dc.identifier.issn2234-3806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160628-
dc.description.abstractBACKGROUND: Grafts survive despite blood group antigens on the transplant being continuously exposed to antibodies in the blood of recipients in ABO-incompatible kidney transplantation (ABOi KT), owing to the mechanism of accommodation. We analyzed the immunodynamics of soluble ABH antigens in allografts from secretor donors and the influence of such immunodynamics on accommodation and subsequent graft survival in ABOi KT. METHODS: The genotype of a known human β-galactoside α-1,2-fucosyltransferase gene (FUT2), which determines soluble ABH antigen secretor status, was established in 32 donors for ABOi KT at the Severance Hospital, from June 2010 to July 2015. Clinical outcomes of recipients, such as anti-A/B antibody titer change, renal function, and graft survival, were evaluated. RESULTS: Twenty-five donors were secretors (78.1%), and seven were nonsecretors (21.9%). The frequency of anti-A/B IgG or IgM antibody titer elevation or reduction post-transplantation was not significantly related to donor secretor status. However, IgM titer was rapidly reduced in recipients transplanted from nonsecretor donors (P=0.01), which could be explained by the lack of absorption effect of soluble antigens, enhancing the binding of antibodies to antigens in the allografts. Interestingly, soluble ABH antigens did not affect rejection-free graft survival, which may be due to the nature of β-galactoside α-1,2-fucosyltransferase. CONCLUSIONS: Soluble ABH antigens produced by transplanted kidneys from secretor donors played a role in inducing accommodation within three months of KT through neutralization; however, major graft outcomes were not affected.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Laboratory Medicine-
dc.relation.isPartOfANNALS OF LABORATORY MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBlood Group Antigens/immunology*-
dc.subject.MESHBlood Group Antigens/metabolism-
dc.subject.MESHBlood Group Incompatibility/immunology*-
dc.subject.MESHCreatinine/blood-
dc.subject.MESHFemale-
dc.subject.MESHFucosyltransferases/genetics-
dc.subject.MESHGenotype-
dc.subject.MESHGraft Rejection/diagnosis-
dc.subject.MESHGraft Rejection/mortality-
dc.subject.MESHHumans-
dc.subject.MESHImmunoglobulin G/blood-
dc.subject.MESHImmunoglobulin G/immunology-
dc.subject.MESHImmunoglobulin M/blood-
dc.subject.MESHImmunoglobulin M/immunology-
dc.subject.MESHKidney Failure, Chronic/therapy-
dc.subject.MESHKidney Transplantation*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSequence Analysis, DNA-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTissue Donors-
dc.subject.MESHTransplantation, Homologous-
dc.titleEffects of Neutralization by Soluble ABH Antigens Produced by Transplanted Kidneys From ABO-Incompatible Secretor Donors-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorJieun Kim-
dc.contributor.googleauthorSinyoung Kim-
dc.contributor.googleauthorIn Sik Hwang-
dc.contributor.googleauthorJong Rak Choi-
dc.contributor.googleauthorJae Geun Lee-
dc.contributor.googleauthorYu Seun Kim-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorHyun Ok Kim-
dc.identifier.doi10.3343/alm.2017.37.3.254-
dc.contributor.localIdA00424-
dc.contributor.localIdA00675-
dc.contributor.localIdA00785-
dc.contributor.localIdA04546-
dc.contributor.localIdA01122-
dc.contributor.localIdA03068-
dc.contributor.localIdA04182-
dc.relation.journalcodeJ00164-
dc.identifier.eissn2234-3814-
dc.identifier.pmid28224772-
dc.subject.keywordBlood group antigens-
dc.subject.keywordBlood group incompatibility-
dc.subject.keywordGraft survival-
dc.subject.keywordKidney transplantation-
dc.subject.keywordβ-galactoside α-1,2-fucosyltransferase-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameKim, Sin Young-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameKim, Jieun-
dc.contributor.alternativeNameKim, Hyun Ok-
dc.contributor.alternativeNameLee, Jae Geun-
dc.contributor.alternativeNameChoi, Jong Rak-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.contributor.affiliatedAuthorKim, Sin Young-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorKim, Jieun-
dc.contributor.affiliatedAuthorKim, Hyun Ok-
dc.contributor.affiliatedAuthorLee, Jae Geun-
dc.contributor.affiliatedAuthorChoi, Jong Rak-
dc.citation.volume37-
dc.citation.number3-
dc.citation.startPage254-
dc.citation.endPage260-
dc.identifier.bibliographicCitationANNALS OF LABORATORY MEDICINE, Vol.37(3) : 254-260, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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