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Successful launch of an ABO-incompatible kidney transplantation program to overcome the shortage of compatible living donors: experience at a single center

DC Field Value Language
dc.contributor.author김명수-
dc.contributor.author김범석-
dc.contributor.author김순일-
dc.contributor.author김신영-
dc.contributor.author김유선-
dc.contributor.author김현옥-
dc.contributor.author이재근-
dc.contributor.author이주한-
dc.contributor.author정현주-
dc.contributor.author허규하-
dc.date.accessioned2018-07-20T07:52:06Z-
dc.date.available2018-07-20T07:52:06Z-
dc.date.issued2017-
dc.identifier.issn0301-0430-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160614-
dc.description.abstractAIMS: ABO-incompatible (ABOi) kidney transplantation (KT) is being increasingly performed to overcome donor shortages. However, debate persists regarding the post-transplant outcomes of ABOi KT vs. that of ABO-compatible (ABOc) KT. METHODS: A total 454 recipients who underwent living-donor KT (LDKT) between June 2010 and July 2014 at Severance Hospital (Seoul) were retrospectively reviewed. 100 ABOi and 354 ABOc KTs were compared. Recipients with a pretransplant positive crossmatch to their donors, pretransplant donor-specific anti-HLA antibody (DSA), or high panel reactive antibody (PRA ≥ 50%) were excluded from both the ABOi and ABOc KT groups. Finally, the authors compared the transplant outcomes of 95 of these ABOi KTs and 121 ABOc KTs performed over the same period. RESULTS: No significant difference in incidence of biopsy-proven acute rejection was observed between the ABOi and ABOc KT groups (p = 0.230), and group glomerular filtration rate of ABOi KT was comparable to that of ABOc KT (p > 0.05 at all time points). 3-year death-censored graft survival rates were similar (96.8 vs. 96.6%, respectively; p = 0.801). However, the incidences of postoperative bleeding, cytomegalovirus infection, fungal infection, and serious infection rates were significantly higher after ABOi KT. CONCLUSIONS: In this study, graft renal function and survival after ABOi KT were excellent, and the incidence of acute rejection was similar to that of ABOc KT. However, efforts are needed to reduce hemorrhagic and infectious complications after ABOi KT. ABOi KT can be a good strategy to overcome ABO antibody barriers and relieve donor shortage.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherDustri-Verlag Dr Karl Feistle-
dc.relation.isPartOfCLINICAL NEPHROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHABO Blood-Group System/immunology*-
dc.subject.MESHAdult-
dc.subject.MESHBlood Group Incompatibility/immunology*-
dc.subject.MESHFemale-
dc.subject.MESHGraft Rejection/epidemiology-
dc.subject.MESHGraft Survival-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHKidney Transplantation*-
dc.subject.MESHLiving Donors*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.titleSuccessful launch of an ABO-incompatible kidney transplantation program to overcome the shortage of compatible living donors: experience at a single center-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorSeung Hwan Song-
dc.contributor.googleauthorJuhan Lee-
dc.contributor.googleauthorBeom Seok Kim-
dc.contributor.googleauthorSinyoung Kim-
dc.contributor.googleauthorJae Geun Lee-
dc.contributor.googleauthorHyeon Joo Jeong-
dc.contributor.googleauthorYu Seun Kim-
dc.contributor.googleauthorMyoung Soo Kim-
dc.contributor.googleauthorHyun Ok Kim-
dc.contributor.googleauthorSoon Il Kim-
dc.contributor.googleauthorKyu Ha Huh-
dc.identifier.doi10.5414/CN109114-
dc.contributor.localIdA00424-
dc.contributor.localIdA00488-
dc.contributor.localIdA00649-
dc.contributor.localIdA00675-
dc.contributor.localIdA00785-
dc.contributor.localIdA01122-
dc.contributor.localIdA03068-
dc.contributor.localIdA03163-
dc.contributor.localIdA03771-
dc.contributor.localIdA04344-
dc.relation.journalcodeJ00588-
dc.identifier.pmid28679466-
dc.identifier.urlhttps://www.dustri.com/nc/article-response-page.html?artId=15902&doi=-
dc.contributor.alternativeNameKim, Myoung Soo-
dc.contributor.alternativeNameKim, Beom Seok-
dc.contributor.alternativeNameKim, Soon Il-
dc.contributor.alternativeNameKim, Sin Young-
dc.contributor.alternativeNameKim, Yu Seun-
dc.contributor.alternativeNameKim, Hyun Ok-
dc.contributor.alternativeNameLee, Jae Geun-
dc.contributor.alternativeNameLee, Ju Han-
dc.contributor.alternativeNameJeong, Hyeon Joo-
dc.contributor.alternativeNameHuh, Kyu Ha-
dc.contributor.affiliatedAuthorKim, Myoung Soo-
dc.contributor.affiliatedAuthorKim, Beom Seok-
dc.contributor.affiliatedAuthorKim, Soon Il-
dc.contributor.affiliatedAuthorKim, Sin Young-
dc.contributor.affiliatedAuthorKim, Yu Seun-
dc.contributor.affiliatedAuthorKim, Hyun Ok-
dc.contributor.affiliatedAuthorLee, Jae Geun-
dc.contributor.affiliatedAuthorLee, Ju Han-
dc.contributor.affiliatedAuthorJeong, Hyeon Joo-
dc.contributor.affiliatedAuthorHuh, Kyu Ha-
dc.citation.volume88-
dc.citation.number9-
dc.citation.startPage117-
dc.citation.endPage123-
dc.identifier.bibliographicCitationCLINICAL NEPHROLOGY, Vol.88(9) : 117-123, 2017-
dc.identifier.rimsid40024-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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