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Repetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain

DC FieldValueLanguage
dc.contributor.author남택상-
dc.contributor.author이배환-
dc.contributor.author차명훈-
dc.date.accessioned2018-07-20T07:51:39Z-
dc.date.available2018-07-20T07:51:39Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160603-
dc.description.abstractRecent evidence indicates that motor cortex stimulation (MCS) is a potentially effective treatment for chronic neuropathic pain. However, the neural mechanisms underlying the attenuated hyperalgesia after MCS are not completely understood. In this study, we investigated the neural mechanism of the effects of MCS using an animal model of neuropathic pain. After 10 daily sessions of MCS, repetitive MCS reduced mechanical allodynia and contributed to neuronal changes in the anterior cingulate cortex (ACC). Interestingly, inhibition of protein kinase M zeta (PKMζ), a regulator of synaptic plasticity, in the ACC blocked the effects of repetitive MCS. Histological and molecular studies showed a significantly increased level of glial fibrillary acidic protein (GFAP) expression in the ACC after peripheral neuropathy, and neither MCS treatment nor ZIP administration affected this increase. These results suggest that repetitive MCS can attenuate the mechanical allodynia in neuropathic pain, and that the activation of PKMζ in the ACC may play a role in the modulation of neuropathic pain via MCS.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRepetitive motor cortex stimulation reinforces the pain modulation circuits of peripheral neuropathic pain-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Physiology-
dc.contributor.googleauthorMyeounghoon Cha-
dc.contributor.googleauthorSun Woo Um-
dc.contributor.googleauthorMinjee Kwon-
dc.contributor.googleauthorTaick Sang Nam-
dc.contributor.googleauthorBae Hwan Lee-
dc.identifier.doi10.1038/s41598-017-08208-2-
dc.contributor.localIdA01271-
dc.contributor.localIdA02791-
dc.contributor.localIdA03994-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid28801619-
dc.contributor.alternativeNameNam, Taick Sang-
dc.contributor.alternativeNameLee, Bae Hwan-
dc.contributor.alternativeNameCha, Myeoung Hoon-
dc.contributor.affiliatedAuthorNam, Taick Sang-
dc.contributor.affiliatedAuthorLee, Bae Hwan-
dc.contributor.affiliatedAuthorCha, Myeoung Hoon-
dc.citation.volume7-
dc.citation.number1-
dc.citation.startPage7986-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.7(1) : 7986, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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