Hyo Sup Shim ; Yoon-La Choi ; Lucia Kim ; Sunhee Chang ; Wan-Seop Kim ; Mee Sook Roh ; Tae-Jung Kim ; Seung Yeon Ha ; Jin-Haeng Chung ; Se Jin Jang ; Geon Kook Lee ; The Korean Cardiopulmonary Pathology Study Group ; and The Korean Molecular Pathology Study Group
Citation
JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, Vol.51(3) : 242-254, 2017
Guideline ; Lung neopla는 ; Molecular testing ; Precision medicine
Abstract
Targeted therapies guided by molecular diagnostics have become a standard treatment of lung cancer. Epidermal growth factor receptor (EGFR) mutations and anaplastic lymphoma kinase (ALK) rearrangements are currently used as the best predictive biomarkers for EGFR tyrosine kinase inhibitors and ALK inhibitors, respectively. Besides EGFR and ALK, the list of druggable genetic alterations has been growing, including ROS1 rearrangements, RET rearrangements, and MET alterations. In this situation, pathologists should carefully manage clinical samples for molecular testing and should do their best to quickly and accurately identify patients who will benefit from precision therapeutics. Here, we grouped molecular biomarkers of lung cancers into three categories-mutations, gene rearrangements, and amplifications-and propose expanded guidelines on molecular testing of lung cancers.