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Fruit and vegetable consumption, Helicobacter pylori antibodies, and gastric cancer risk: A pooled analysis of prospective studies in China, Japan, and Korea

DC FieldValueLanguage
dc.contributor.author지선하-
dc.date.accessioned2018-07-20T07:50:59Z-
dc.date.available2018-07-20T07:50:59Z-
dc.date.issued2017-
dc.identifier.issn0020-7136-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160587-
dc.description.abstractEpidemiological findings on the association between fruit and vegetable consumption and gastric cancer risk remain inconsistent. The present analysis included 810 prospectively ascertained non-cardia gastric cancer cases and 1,160 matched controls from the Helicobacter pylori Biomarker Cohort Consortium, which collected blood samples, demographic, lifestyle, and dietary data at baseline. Conditional logistic regression adjusting for total energy intake, smoking, and H. pylori status, was applied to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for gastric cancer risk across cohort- and sex-specific quartiles of fruit and vegetable intake. Increasing fruit intake was associated with decreasing risk of non-cardia gastric cancer (OR = 0.71, 95% CI: 0.52-0.95, p trend = 0.02). Compared to low-fruit consumers infected with CagA-positive H. pylori, high-fruit consumers without evidence of H. pylori antibodies had the lowest odds for gastric cancer incidence (OR = 0.12, 95% CI: 0.06-0.25), whereby the inverse association with high-fruit consumption was attenuated among individuals infected with CagA-positive H. pylori (OR = 0.82, 95% CI: 0.66-1.03). To note, the small number of H. pylori negative individuals does influence this finding. We observed a weaker, nondose-response suggestion of an inverse association of vegetable intake with non-cardia gastric cancer risk. High fruit intake may play a role in decreasing risk of non-cardia gastric cancer in Asia.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CANCER-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAntibodies, Bacterial/immunology*-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHChina-
dc.subject.MESHDiet-
dc.subject.MESHEnergy Intake/physiology-
dc.subject.MESHFemale-
dc.subject.MESHFruit-
dc.subject.MESHHelicobacter Infections/complications*-
dc.subject.MESHHelicobacter Infections/immunology-
dc.subject.MESHHelicobacter pylori-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHJapan-
dc.subject.MESHLife Style-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRisk Factors-
dc.subject.MESHStomach Neoplasms/etiology*-
dc.subject.MESHStomach Neoplasms/microbiology-
dc.subject.MESHVegetables-
dc.titleFruit and vegetable consumption, Helicobacter pylori antibodies, and gastric cancer risk: A pooled analysis of prospective studies in China, Japan, and Korea-
dc.typeArticle-
dc.contributor.collegeGraduate School of Public Health-
dc.contributor.departmentGraduate School of Public Health-
dc.contributor.googleauthorTianyi Wang-
dc.contributor.googleauthorHui Cai-
dc.contributor.googleauthorShizuka Sasazuki-
dc.contributor.googleauthorShoichiro Tsugane-
dc.contributor.googleauthorWei Zheng-
dc.contributor.googleauthorEo Rin Cho-
dc.contributor.googleauthorSun Ha Jee-
dc.contributor.googleauthorAngelika Michel-
dc.contributor.googleauthorMichael Pawlita-
dc.contributor.googleauthorYong-Bing Xiang-
dc.contributor.googleauthorYu-Tang Gao-
dc.contributor.googleauthorXiao-Ou Shu-
dc.contributor.googleauthorWei-Cheng You-
dc.contributor.googleauthorMeira Epplein-
dc.identifier.doi10.1002/ijc.30477-
dc.contributor.localIdA03965-
dc.relation.journalcodeJ01092-
dc.identifier.eissn1097-0215-
dc.identifier.pmid27759938-
dc.subject.keywordHelicobacter pylori-
dc.subject.keyworddiet-
dc.subject.keywordfruit-
dc.subject.keywordstomach neoplasms-
dc.subject.keywordvegetables-
dc.contributor.alternativeNameJee, Sun Ha-
dc.contributor.affiliatedAuthorJee, Sun Ha-
dc.citation.volume140-
dc.citation.number3-
dc.citation.startPage591-
dc.citation.endPage599-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CANCER, Vol.140(3) : 591-599, 2017-
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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