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Transient neonatal myasthenia gravis due to a mother with ocular onset of anti-muscle specific kinase myasthenia gravis

Authors
 Ju-Yeun Lee  ;  Ju-Hong Min  ;  Sueng-Han Han  ;  Jinu Han 
Citation
 Neuromuscular Disorders, Vol.27(7) : 655-657, 2017 
Journal Title
 Neuromuscular Disorders 
ISSN
 0960-8966 
Issue Date
2017
MeSH
Adult ; Autoantibodies/blood ; Autoantibodies/immunology ; Blepharoptosis/etiology ; Female ; Humans ; Myasthenia Gravis/complications ; Myasthenia Gravis/immunology ; Myasthenia Gravis, Neonatal ; Pregnancy ; Pregnancy Complications/immunology ; Receptor Protein-Tyrosine Kinases/immunology ; Receptors, Cholinergic/immunology
Keywords
Anti-muscle-specific kinase ; Ocular myasthenia gravis ; Pregnancy ; Transient neonatal myasthenia gravis
Abstract
We describe a 27-year-old pregnant female with new onset of conjugate gaze deficit during the third trimester of pregnancy. Repetitive nerve stimulation tests, neostigmine tests, and acetylcholine receptor antibody assays were all negative. The patient delivered a normal healthy baby at a local clinic via cesarean section. The baby became hypotonic and had respiratory failure several minutes after birth. The result of acetylcholine receptor antibody was negative in the neonate. The neonate became healthy spontaneously and was extubated after 21 days of ventilation care. Two months after delivery, the mother developed ptosis and generalized symptoms and subsequent workup revealed she was muscle specific kinase (MuSK) antibody positive. The neonate was presumed to have an anti-MuSK-mediated transient neonatal myasthenia gravis. Although MuSK antibody testing is rarely indicated in ocular myasthenia gravis, MuSK antibody testing is necessary in pregnant women who are presumed ocular myasthenia gravis to warn occurrence of transient neonatal myasthenia gravis.
Full Text
https://www.sciencedirect.com/science/article/pii/S0960896617300639
DOI
10.1016/j.nmd.2017.03.012
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Han, Seung Han(한승한) ORCID logo https://orcid.org/0000-0001-8972-4790
Han, Jinu(한진우) ORCID logo https://orcid.org/0000-0002-8607-6625
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160577
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