Cited 49 times in
Current Strategies and Challenges for Purification of Cardiomyocytes Derived from Human Pluripotent Stem Cells
DC Field | Value | Language |
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dc.contributor.author | 윤영섭 | - |
dc.date.accessioned | 2018-07-20T07:49:46Z | - |
dc.date.available | 2018-07-20T07:49:46Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160561 | - |
dc.description.abstract | Cardiomyocytes (CMs) derived from human pluripotent stem cells (hPSCs) are considered a most promising option for cell-based cardiac repair. Hence, various protocols have been developed for differentiating hPSCs into CMs. Despite remarkable improvement in the generation of hPSC-CMs, without purification, these protocols can only generate mixed cell populations including undifferentiated hPSCs or non-CMs, which may elicit adverse outcomes. Therefore, one of the major challenges for clinical use of hPSC-CMs is the development of efficient isolation techniques that allow enrichment of hPSC-CMs. In this review, we will discuss diverse strategies that have been developed to enrich hPSC-CMs. We will describe major characteristics of individual hPSC-CM purification methods including their scientific principles, advantages, limitations, and needed improvements. Development of a comprehensive system which can enrich hPSC-CMs will be ultimately useful for cell therapy for diseased hearts, human cardiac disease modeling, cardiac toxicity screening, and cardiac tissue engineering. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Ivyspring International Publisher | - |
dc.relation.isPartOf | THERANOSTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Cell Differentiation | - |
dc.subject.MESH | Cell Separation/methods* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Myocytes, Cardiac/physiology* | - |
dc.subject.MESH | Pluripotent Stem Cells/physiology* | - |
dc.title | Current Strategies and Challenges for Purification of Cardiomyocytes Derived from Human Pluripotent Stem Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | Kiwon Ban | - |
dc.contributor.googleauthor | Seongho Bae | - |
dc.contributor.googleauthor | Young-sup Yoon | - |
dc.identifier.doi | 10.7150/thno.19427 | - |
dc.contributor.localId | A02579 | - |
dc.relation.journalcode | J03103 | - |
dc.identifier.eissn | 1838-7640 | - |
dc.identifier.pmid | 28638487 | - |
dc.subject.keyword | Cardiomyocytes | - |
dc.subject.keyword | hPSCs | - |
dc.contributor.alternativeName | Yoon, Young Sup | - |
dc.contributor.affiliatedAuthor | Yoon, Young Sup | - |
dc.citation.volume | 7 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2067 | - |
dc.citation.endPage | 2077 | - |
dc.identifier.bibliographicCitation | THERANOSTICS, Vol.7(7) : 2067-2077, 2017 | - |
dc.identifier.rimsid | 47642 | - |
dc.type.rims | ART | - |
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