Cited 11 times in
Predictors of mortality in autoimmune disease patients with concurrent cytomegalovirus infections detected by quantitative real-time PCR.
DC Field | Value | Language |
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dc.contributor.author | 박용범 | - |
dc.contributor.author | 송정식 | - |
dc.contributor.author | 안성수 | - |
dc.contributor.author | 이경용 | - |
dc.contributor.author | 이상원 | - |
dc.contributor.author | 이혁민 | - |
dc.contributor.author | 정승민 | - |
dc.date.accessioned | 2018-07-20T07:49:30Z | - |
dc.date.available | 2018-07-20T07:49:30Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160557 | - |
dc.description.abstract | OBJECTIVE: Cytomegaloviruses (CMV) can have a significant impact on the prognosis of immunocompromised patients. Unlike in the transplantation and AIDS fields, only a few studies on CMV infections have been published in the field of autoimmunity. In this study, we examined the clinical outcomes of CMV infections in patients with autoimmune diseases at a single tertiary medical institution. METHODS: A retrospective study was performed to identify the mortality risk factors associated with CMV infections in patients with autoimmune diseases. We reviewed the medical records of patients with autoimmune diseases who were diagnosed with CMV infections using real-time quantitative polymerase chain reaction between December 2005 and March 2016. Clinical and laboratory parameters as well as treatment outcomes were analyzed. RESULTS: Seventy-three CMV infected patients were separated into survivors and non-survivors. Non-survivors had significantly higher median CMV-DNA copy numbers than survivors (95,500 vs 6,700 copies/mL, p = 0.005) and demonstrated significantly more frequent incidents of CMV pneumonitis (69.2 vs 36.2%, p = 0.007). After adjusting for multiple confounding covariates, the log CMV-DNA copies/mL (hazard ratio, 1.48; 95% confidence interval, 1.14-1.92; p = 0.003) and the presence of concurrent infections (hazard ratio, 22.00; 95% confidence interval, 2.75-175.97, p = 0.004) were identified as independent mortality risk factors. Furthermore, patients with high CMV copy numbers (> 60,000 copies/mL) had higher in-hospital mortality than those with low CMV copy numbers (p < 0.05). CONCLUSIONS: CMV-DNA copy numbers and concurrent infections are predictors of in-hospital mortality in CMV-infected patients with autoimmune diseases. Therefore, serial measurements of CMV-DNA copy numbers and close observation for signs of other infections are recommended for patients with autoimmune diseases who have concurrent CMV infection | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Antiviral Agents/therapeutic use | - |
dc.subject.MESH | Autoimmune Diseases/complications | - |
dc.subject.MESH | Autoimmune Diseases/drug therapy | - |
dc.subject.MESH | Autoimmune Diseases/mortality | - |
dc.subject.MESH | Autoimmune Diseases/virology | - |
dc.subject.MESH | Cytomegalovirus/drug effects | - |
dc.subject.MESH | Cytomegalovirus/genetics | - |
dc.subject.MESH | Cytomegalovirus/isolation & purification | - |
dc.subject.MESH | Cytomegalovirus Infections/complications | - |
dc.subject.MESH | Cytomegalovirus Infections/diagnosis | - |
dc.subject.MESH | Cytomegalovirus Infections/drug therapy | - |
dc.subject.MESH | DNA, Viral/analysis | - |
dc.subject.MESH | DNA, Viral/genetics | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Ganciclovir/therapeutic use | - |
dc.subject.MESH | Hospital Mortality | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunosuppressive Agents/therapeutic use | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Real-Time Polymerase Chain Reaction | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Predictors of mortality in autoimmune disease patients with concurrent cytomegalovirus infections detected by quantitative real-time PCR. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Kyoung Yong Lee | - |
dc.contributor.googleauthor | Byung-Woo Yoo | - |
dc.contributor.googleauthor | Sung Soo Ahn | - |
dc.contributor.googleauthor | William Han Bae | - |
dc.contributor.googleauthor | Hyukmin Lee | - |
dc.contributor.googleauthor | Seung Min Jung | - |
dc.contributor.googleauthor | Sang-Won Lee | - |
dc.contributor.googleauthor | Yong-Beom Park | - |
dc.contributor.googleauthor | Jason Jungsik Song | - |
dc.identifier.doi | 10.1371/journal.pone.0181590 | - |
dc.contributor.localId | A01579 | - |
dc.contributor.localId | A02057 | - |
dc.contributor.localId | A02233 | - |
dc.contributor.localId | A05371 | - |
dc.contributor.localId | A02824 | - |
dc.contributor.localId | A03286 | - |
dc.contributor.localId | A05179 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 28742877 | - |
dc.contributor.alternativeName | Park, Yong Beom | - |
dc.contributor.alternativeName | Song, Jung Sik | - |
dc.contributor.alternativeName | Ahn, Sung Soo | - |
dc.contributor.alternativeName | Lee, Kyoung Yong | - |
dc.contributor.alternativeName | Lee, Sang Won | - |
dc.contributor.alternativeName | Lee, Hyuk Min | - |
dc.contributor.alternativeName | Jung, SeungMin | - |
dc.contributor.affiliatedAuthor | Park, Yong Beom | - |
dc.contributor.affiliatedAuthor | Song, Jung Sik | - |
dc.contributor.affiliatedAuthor | Ahn, Sung Soo | - |
dc.contributor.affiliatedAuthor | Lee, Kyoung Yong | - |
dc.contributor.affiliatedAuthor | Lee, Sang Won | - |
dc.contributor.affiliatedAuthor | Lee, Hyuk Min | - |
dc.contributor.affiliatedAuthor | Jung, SeungMin | - |
dc.citation.volume | 12 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | e0181590 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.12(7) : e0181590, 2017 | - |
dc.identifier.rimsid | 47638 | - |
dc.type.rims | ART | - |
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