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Application of the 2016 EULAR/ACR/PRINTO Classification Criteria for Macrophage Activation Syndrome in Patients with Adult-onset Still Disease

DC Field Value Language
dc.contributor.author박용범-
dc.contributor.author송정식-
dc.contributor.author안성수-
dc.contributor.author이상원-
dc.contributor.author정승민-
dc.date.accessioned2018-07-20T07:49:26Z-
dc.date.available2018-07-20T07:49:26Z-
dc.date.issued2017-
dc.identifier.issn0315-162X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160556-
dc.description.abstractOBJECTIVE: To evaluate the clinical significance of the 2016 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR)/Pediatric Rheumatology International Trials Organization (PRINTO) classification criteria for macrophage activation syndrome (MAS) in patients with adult-onset Still disease (AOSD). METHODS: We performed a retrospective analysis of patients with AOSD with fever who were admitted to Severance Hospital between 2005 and 2016. The patients with AOSD were evaluated for MAS using the 2016 classification criteria for MAS. Clinical features, laboratory findings, and overall survival were analyzed. Logistic regression analysis was used to evaluate the factors associated with in-hospital mortality. RESULTS: Among 64 patients with AOSD, 36 (56.3%) were classified as having MAS. The overall survival rate was significantly lower in patients with MAS than in those without (67% vs 100%, p < 0.001). Multivariate analysis showed that a low erythrocyte sedimentation rate, a low albumin level, an increase in ferritin of over 2 folds, and the development of MAS on admission were significantly associated with mortality in patients with AOSD. CONCLUSION: The 2016 EULAR/ACR/PRINTO classification criteria for MAS are potentially useful for the identification of patients with AOSD at high risk for a poor outcome. Febrile patients with AOSD should be monitored with the 2016 classification criteria for MAS in the early diagnosis and proper treatment of MAS.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherJournal Of Rheumatology Publishing Co.-
dc.relation.isPartOfJOURNAL OF RHEUMATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBlood Sedimentation-
dc.subject.MESHFemale-
dc.subject.MESHFerritins/blood-
dc.subject.MESHHospital Mortality-
dc.subject.MESHHumans-
dc.subject.MESHMacrophage Activation Syndrome/blood-
dc.subject.MESHMacrophage Activation Syndrome/complications-
dc.subject.MESHMacrophage Activation Syndrome/diagnosis*-
dc.subject.MESHMacrophage Activation Syndrome/mortality-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSerum Albumin/analysis-
dc.subject.MESHStill's Disease, Adult-Onset/blood-
dc.subject.MESHStill's Disease, Adult-Onset/complications*-
dc.subject.MESHStill's Disease, Adult-Onset/mortality-
dc.titleApplication of the 2016 EULAR/ACR/PRINTO Classification Criteria for Macrophage Activation Syndrome in Patients with Adult-onset Still Disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSung Soo Ahn-
dc.contributor.googleauthorByung-Woo Yoo-
dc.contributor.googleauthorSeung Min Jung-
dc.contributor.googleauthorSang-Won Lee-
dc.contributor.googleauthorYong-Beom Park-
dc.contributor.googleauthorJason Jungsik Song-
dc.identifier.doi10.3899/jrheum.161286-
dc.contributor.localIdA01579-
dc.contributor.localIdA02057-
dc.contributor.localIdA02233-
dc.contributor.localIdA02824-
dc.contributor.localIdA05179-
dc.relation.journalcodeJ01738-
dc.identifier.pmid28412707-
dc.identifier.urlhttp://www.jrheum.org/content/44/7/996-
dc.subject.keywordADULT-ONSET STILL DISEASE-
dc.subject.keywordFERRITIN-
dc.subject.keywordMACROPHAGE ACTIVATION SYNDROME-
dc.subject.keywordSYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS-
dc.contributor.alternativeNamePark, Yong Beom-
dc.contributor.alternativeNameSong, Jung Sik-
dc.contributor.alternativeNameAhn, Sung Soo-
dc.contributor.alternativeNameLee, Sang Won-
dc.contributor.alternativeNameJung, SeungMin-
dc.contributor.affiliatedAuthorPark, Yong Beom-
dc.contributor.affiliatedAuthorSong, Jung Sik-
dc.contributor.affiliatedAuthorAhn, Sung Soo-
dc.contributor.affiliatedAuthorLee, Sang Won-
dc.contributor.affiliatedAuthorJung, SeungMin-
dc.citation.volume44-
dc.citation.number7-
dc.citation.startPage996-
dc.citation.endPage1003-
dc.identifier.bibliographicCitationJOURNAL OF RHEUMATOLOGY, Vol.44(7) : 996-1003, 2017-
dc.identifier.rimsid44791-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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