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Repetitive Nerve Stimulation in MuSK-Antibody-Positive Myasthenia Gravis

DC FieldValueLanguage
dc.contributor.author김승민-
dc.contributor.author김승우-
dc.contributor.author신하영-
dc.date.accessioned2018-07-20T07:49:23Z-
dc.date.available2018-07-20T07:49:23Z-
dc.date.issued2017-
dc.identifier.issn1738-6586-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160555-
dc.description.abstractBACKGROUND AND PURPOSE: Responses to repetitive nerve stimulation (RNS) in patients with muscle-specific tyrosine kinase (MuSK) antibody (Ab)-positive myasthenia gravis (MG) vary depending on the muscles tested. We analyzed the RNS responses of limb and facial muscles in MuSK-Ab-positive and acetylcholine receptor (AChR)-Ab-negative MG (MuSK MG) and MuSK-Ab-negative and AChR-Ab-negative [double-seronegative (DSN)] MG patients. METHODS: We retrospectively compared RNS responses between 45 MuSK MG and 29 DSN MG. RNS was applied to the abductor digiti minimi, flexor carpi ulnaris, trapezius, orbicularis oculi, and nasalis muscles. RESULTS: Abnormal RNS responses in limb muscles were observed in 22.2 and 58.6% of MuSK MG and DSN MG patients, respectively, with abnormal facial responses observed in 77.8 and 65.5%, and abnormal responses observed in any of the five muscles in 86.7 and 72.4%. Abnormal RNS responses in the abductor digiti minimi or flexor carpi ulnaris were less frequent in MuSK MG (8.9 and 15.6%, respectively) than in DSN MG (37.9 and 55.2%), whereas the findings for other muscles were not significantly different between the groups. Abnormal facial responses but normal limb responses were independently associated with MuSK MG (odds ratio=5.224, 95% confidence interval=1.300-20.990). CONCLUSIONS: Abnormal RNS responses primarily in facial muscles without involvement of limb muscles were more pronounced in MuSK MG than in DSN MG. RNS of both facial and limb muscles in AChR-Ab-negative MG can increase the test sensitivity and aid in early suspicion of MuSK MG.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Neurological Association-
dc.relation.isPartOfJOURNAL OF CLINICAL NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRepetitive Nerve Stimulation in MuSK-Antibody-Positive Myasthenia Gravis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorSeung Woo Kim-
dc.contributor.googleauthorMun Kyung Sunwoo-
dc.contributor.googleauthorSeung Min Kim-
dc.contributor.googleauthorHa Young Shin-
dc.contributor.googleauthorIl Nam Sunwoo-
dc.identifier.doi10.3988/jcn.2017.13.3.287-
dc.contributor.localIdA00653-
dc.contributor.localIdA04901-
dc.contributor.localIdA02170-
dc.relation.journalcodeJ01327-
dc.identifier.eissn2005-5013-
dc.identifier.pmid28516744-
dc.subject.keywordMuSK-
dc.subject.keywordacetylcholine receptor-
dc.subject.keywordmuscle-specific tyrosine kinase-
dc.subject.keywordmyasthenia gravis-
dc.subject.keywordrepetitive nerve stimulation-
dc.contributor.alternativeNameKim, Seung Min-
dc.contributor.alternativeNameKim, Seung Woo-
dc.contributor.alternativeNameShin, Ha Young-
dc.contributor.affiliatedAuthorKim, Seung Min-
dc.contributor.affiliatedAuthorKim, Seung Woo-
dc.contributor.affiliatedAuthorShin, Ha Young-
dc.citation.volume13-
dc.citation.number3-
dc.citation.startPage287-
dc.citation.endPage292-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL NEUROLOGY, Vol.13(3) : 287-292, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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