272 465

Cited 7 times in

Value of Serum Cystatin C Measurement in the Diagnosis of Sepsis-Induced Kidney Injury and Prediction of Renal Function Recovery.

DC Field Value Language
dc.contributor.author강영애-
dc.contributor.author김송이-
dc.contributor.author김영삼-
dc.contributor.author김은영-
dc.contributor.author박무석-
dc.contributor.author송주한-
dc.contributor.author임아영-
dc.contributor.author장준-
dc.contributor.author정경수-
dc.contributor.author정지예-
dc.date.accessioned2018-07-20T07:48:49Z-
dc.date.available2018-07-20T07:48:49Z-
dc.date.issued2017-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160550-
dc.description.abstractPURPOSE: Acute kidney injury (AKI) is common in critically ill patients. Serum cystatin C has emerged as a reliable marker of AKI. We sought to assess the value of serum cystatin C for early detection and prediction of renal function recovery in patients with sepsis. MATERIALS AND METHODS: Sepsis patients (113 AKI patients and 49 non-AKI patients) admitted to the intensive care unit (ICU) were included. Serum creatinine and cystatin C levels and glomerular filtration rate were measured on days 0, 1, 3, and 7. RESULTS: Serum cystatin C levels were significantly higher in AKI patients than in non-AKI patients at all time points. Multivariate analysis showed that only serum cystatin C levels on day 0 were associated with AKI development [odds ratio (OR)=19.30; 95% confidence interval (CI)= 2.58-144.50, p<0.001]. Linear mixed model analysis showed significant variation in cystatin C levels between the recovery and non-recovery groups over time (p=0.001). High levels of serum cystatin C at day 0 (OR=1.64; 95% CI=1.00-2.68, p=0.048) were associated with recovery of AKI. CONCLUSION: Serum cystatin C level was found to be associated with the development and worsening of AKI in ICU patients with sepsis.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Kidney Injury/blood*-
dc.subject.MESHAcute Kidney Injury/diagnosis*-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCreatinine/blood*-
dc.subject.MESHCritical Care-
dc.subject.MESHCritical Illness-
dc.subject.MESHCystatin C/blood*-
dc.subject.MESHDisease Progression-
dc.subject.MESHEarly Diagnosis-
dc.subject.MESHFemale-
dc.subject.MESHGlomerular Filtration Rate-
dc.subject.MESHHumans-
dc.subject.MESHIntensive Care Units-
dc.subject.MESHKidney Function Tests-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHProspective Studies-
dc.subject.MESHRecovery of Function-
dc.subject.MESHSensitivity and Specificity-
dc.subject.MESHSepsis/blood-
dc.subject.MESHSepsis/complications-
dc.subject.MESHSepsis/diagnosis*-
dc.subject.MESHTime Factors-
dc.titleValue of Serum Cystatin C Measurement in the Diagnosis of Sepsis-Induced Kidney Injury and Prediction of Renal Function Recovery.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorAh Young Leem-
dc.contributor.googleauthorMoo Suk Park-
dc.contributor.googleauthorByung Hoon Park-
dc.contributor.googleauthorWon Jai Jung-
dc.contributor.googleauthorKyung Soo Chung-
dc.contributor.googleauthorSong Yee Kim-
dc.contributor.googleauthorEun Young Kim-
dc.contributor.googleauthorJi Ye Jung-
dc.contributor.googleauthorYoung Ae Kang-
dc.contributor.googleauthorYoung Sam Kim-
dc.contributor.googleauthorSe Kyu Kim-
dc.contributor.googleauthorJoon Chang-
dc.contributor.googleauthorJoo Han Song-
dc.identifier.doi10.3349/ymj.2017.58.3.604-
dc.contributor.localIdA00057-
dc.contributor.localIdA00626-
dc.contributor.localIdA00707-
dc.contributor.localIdA00811-
dc.contributor.localIdA01457-
dc.contributor.localIdA02062-
dc.contributor.localIdA03382-
dc.contributor.localIdA03472-
dc.contributor.localIdA03570-
dc.contributor.localIdA03735-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid28332367-
dc.subject.keywordSepsis-
dc.subject.keywordacute kidney injury-
dc.subject.keywordcystatin C-
dc.contributor.alternativeNameKang, Young Ae-
dc.contributor.alternativeNameKim, Song Yi-
dc.contributor.alternativeNameKim, Young Sam-
dc.contributor.alternativeNameKim, Eun Young-
dc.contributor.alternativeNamePark, Moo Suk-
dc.contributor.alternativeNameSong, Joo Han-
dc.contributor.alternativeNameLeem, Ah Young-
dc.contributor.alternativeNameChang, Joon-
dc.contributor.alternativeNameJung, Kyung Soo-
dc.contributor.alternativeNameJung, Ji Ye-
dc.contributor.affiliatedAuthorKang, Young Ae-
dc.contributor.affiliatedAuthorKim, Song Yi-
dc.contributor.affiliatedAuthorKim, Young Sam-
dc.contributor.affiliatedAuthorKim, Eun Young-
dc.contributor.affiliatedAuthorPark, Moo Suk-
dc.contributor.affiliatedAuthorSong, Joo Han-
dc.contributor.affiliatedAuthorLeem, Ah Young-
dc.contributor.affiliatedAuthorChang, Joon-
dc.contributor.affiliatedAuthorJung, Kyung Soo-
dc.contributor.affiliatedAuthorJung, Ji Ye-
dc.citation.volume58-
dc.citation.number3-
dc.citation.startPage604-
dc.citation.endPage612-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.58(3) : 604-612, 2017-
dc.identifier.rimsid44785-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.