Cited 13 times in
Daily use of sildenafil 50mg at night effectively ameliorates nocturia in patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: an exploratory multicenter, double-blind, randomized, placebo-controlled study
DC Field | Value | Language |
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dc.contributor.author | 함원식 | - |
dc.contributor.author | 한현호 | - |
dc.date.accessioned | 2018-07-20T07:48:19Z | - |
dc.date.available | 2018-07-20T07:48:19Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1368-5538 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160539 | - |
dc.description.abstract | PURPOSE: To compare the efficacy and safety of sildenafil 25 mg qd, 25 mg bid or 50 mg qd - on treating lower urinary tract symptoms with benign prostatic hyperplasia (LUTS/BPH). MATERIALS AND METHODS: Men aged > 45 years with LUTS/BPH were randomly assigned to receive sildenafil 25 mg qd (n = 42), bid (n = 41), 50 mg qd (n = 38) or placebo (n = 41) for 8 weeks. Changes from baseline in International Prostate Symptom Score (I-PSS), maximum urinary flow rate (Qmax) and postvoid residual urine volume (PVR) were assessed at week 4 and week 8. RESULTS: Sildenafil 25 mg qd (-7.3 ± 5.8) and 25 mg bid (-7.0 ± 5.7) exhibited significant improvements of I-PSS compared to placebo (-5.2 ± 6.4) (p = 0.020, 0.025, respectively). In particular, voiding domain was more affected than storage domain. Only sildenafil 50 mg qd improved nocturia significantly (versus placebo, p = 0.027). Quality of life score was improved in all treatment groups. Qmax and PVR did not change significantly in all groups. All regimens were well tolerated. CONCLUSIONS: Sildenafil 25 mg qd, 25 mg bid and 50 mg qd are safe and effective to improve LUTS/BPH in long term, along with coexisting ED. In particular, nocturia is most well-controlled by 50 mg qd. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | England | - |
dc.publisher | 1473-0790 | - |
dc.relation.isPartOf | AGING MALE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Erectile Dysfunction/complications | - |
dc.subject.MESH | Erectile Dysfunction/drug therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Nocturia/complications | - |
dc.subject.MESH | Nocturia/drug therapy* | - |
dc.subject.MESH | Nocturia/psychology | - |
dc.subject.MESH | Phosphodiesterase 5 Inhibitors/administration & dosage* | - |
dc.subject.MESH | Prostatic Hyperplasia/complications* | - |
dc.subject.MESH | Quality of Life | - |
dc.subject.MESH | Sildenafil Citrate/administration & dosage* | - |
dc.subject.MESH | Urination | - |
dc.title | Daily use of sildenafil 50mg at night effectively ameliorates nocturia in patients with lower urinary tract symptoms associated with benign prostatic hyperplasia: an exploratory multicenter, double-blind, randomized, placebo-controlled study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Urology | - |
dc.contributor.googleauthor | Woo Jin Ko | - |
dc.contributor.googleauthor | Hyun Ho Han | - |
dc.contributor.googleauthor | Won Sik Ham | - |
dc.contributor.googleauthor | Hae Won Lee | - |
dc.identifier.doi | 10.1080/13685538.2016.1204290 | - |
dc.contributor.localId | A04337 | - |
dc.relation.journalcode | J03318 | - |
dc.identifier.eissn | 1473-0790 | - |
dc.identifier.pmid | 28590828 | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.1080/13685538.2016.1204290 | - |
dc.subject.keyword | Benign prostatic hyperplasia | - |
dc.subject.keyword | erectile dysfunction | - |
dc.subject.keyword | lower urinary tract symptom | - |
dc.subject.keyword | nitric oxide pathway | - |
dc.subject.keyword | nocturia | - |
dc.subject.keyword | phosphodiesterase 5 inhibitor | - |
dc.contributor.alternativeName | Ham, Won Sik | - |
dc.contributor.affiliatedAuthor | Ham, Won Sik | - |
dc.citation.volume | 20 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 81 | - |
dc.citation.endPage | 88 | - |
dc.identifier.bibliographicCitation | AGING MALE, Vol.20(2) : 81-88, 2017 | - |
dc.identifier.rimsid | 44774 | - |
dc.type.rims | ART | - |
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