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Using transient elastography to predict hepatocellular carcinoma recurrence after radiofrequency ablation

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dc.contributor.author김도영-
dc.contributor.author김범경-
dc.contributor.author김승업-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author한광협-
dc.date.accessioned2018-07-20T07:47:49Z-
dc.date.available2018-07-20T07:47:49Z-
dc.date.issued2017-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160532-
dc.description.abstractBACKGROUND AND AIM: Liver stiffness (LS) value determined using transient elastography (TE) can be used to assess the degree of liver fibrosis. The study investigated whether TE can predict the recurrence of hepatocellular carcinoma (HCC) after radiofrequency ablation (RFA). METHODS: This study retrospectively enrolled 228 patients with HCC who received TE and RFA as the first-line treatment for HCC between 2008 and 2015. Cox regression analysis was used to identify independent predictors of HCC recurrence. RESULTS: The median age of the study population (170 men and 58 women) was 61 years. During the study period, HCC recurrence and mortality developed in 125 (54.8%) and 37 (16.2%) patients after RFA, respectively. Liver cirrhosis, platelet count, multiple tumors, and LS value were the independent predictors of HCC recurrence. When the study population was stratified into early (< 12 months) and late (≥ 12 months) recurrence groups, LS value was an independent predictor of late recurrence, along with liver cirrhosis and spleen diameter. The risk of late recurrence was higher in patients with LS values of ≥ 13 kPa than in those with LS values of < 13 kPa (adjusted hazard ratio [HR] = 4.507, 95% confidence interval [CI] 2.131-7.724, P < 0.001). Recurrence was the only predictor of overall survival (HR = 18.583, 95% CI 2.424-142.486, P = 0.005). CONCLUSIONS: Findings of this study suggest that LS measurement using TE can be a useful predictor of HCC recurrence after RFA.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Scientific Publications-
dc.relation.isPartOfJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCarcinoma, Hepatocellular/diagnostic imaging*-
dc.subject.MESHCarcinoma, Hepatocellular/surgery*-
dc.subject.MESHCatheter Ablation*-
dc.subject.MESHElasticity Imaging Techniques/methods*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLiver/diagnostic imaging*-
dc.subject.MESHLiver Cirrhosis/diagnostic imaging*-
dc.subject.MESHLiver Neoplasms/diagnostic imaging*-
dc.subject.MESHLiver Neoplasms/surgery*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Recurrence, Local*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titleUsing transient elastography to predict hepatocellular carcinoma recurrence after radiofrequency ablation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorYu Rim Lee-
dc.contributor.googleauthorSoo Young Park-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorSe Young Jang-
dc.contributor.googleauthorWon Young Tak-
dc.contributor.googleauthorYoung Oh Kweon-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorKwang‐Hyub Han-
dc.contributor.googleauthorKeun Hur-
dc.identifier.doi10.1111/jgh.13644-
dc.contributor.localIdA00385-
dc.contributor.localIdA00487-
dc.contributor.localIdA00654-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA04268-
dc.relation.journalcodeJ01417-
dc.identifier.eissn1440-1746-
dc.identifier.pmid27859615-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.13644-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordliver stiffness-
dc.subject.keywordradiofrequency ablation-
dc.subject.keywordrecurrence-
dc.subject.keywordtransient elastography-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.contributor.affiliatedAuthorKim, Beom Kyung-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.citation.volume32-
dc.citation.number5-
dc.citation.startPage1079-
dc.citation.endPage1086-
dc.identifier.bibliographicCitationJOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.32(5) : 1079-1086, 2017-
dc.identifier.rimsid44266-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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