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Gamma-glutamyl transpeptidase-to-platelet ratio is an independent predictor of hepatitis B virus-related liver cancer

DC FieldValueLanguage
dc.contributor.author김도영-
dc.contributor.author김범경-
dc.contributor.author김승업-
dc.contributor.author박용은-
dc.contributor.author박준용-
dc.contributor.author안상훈-
dc.contributor.author전미영-
dc.contributor.author한광협-
dc.contributor.author한소정-
dc.date.accessioned2018-07-20T07:47:40Z-
dc.date.available2018-07-20T07:47:40Z-
dc.date.issued2017-
dc.identifier.issn0815-9319-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160531-
dc.description.abstractBACKGROUND AND AIM: Gamma-glutamyl transpeptidase-to-platelet ratio (GPR) can evaluate the degree of liver fibrosis. We investigated whether GPR can predict the development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients. METHODS: We retrospectively evaluated 1109 CHB patients that were enrolled between 2006 and 2012, and all patients had available data for the assessment of GPR at enrollment. Three risk groups were defined according to tertile stratification: GPR < 0.05, low-risk (n = 370 [33.4%]); GPR 0.05-0.24, intermediate-risk (n = 370 [33.4%]); and GPR > 0.24, high-risk (n = 369 [33.2%]). The predictive accuracy of GPR, fibrosis-4 (FIB-4), and aspartate transaminase-to-platelet ratio index (APRI) in predicting HCC development was tested. RESULTS: The median age of the study population (746 men and 363 women) was 50 years. During the follow-up period (median, 32 months; interquartile range, 19-57 months), 69 (6.2%) patients developed HCC. Together with age, male gender, diabetes mellitus, antiviral therapy, serum albumin, and alpha-fetoprotein, the relative risk of HCC development significantly increased from low-risk to high-risk GPR groups (hazard ratio [HR], up to 29.5; adjusted HR, up to 10.6; all P < 0.05). In addition, FIB-4 was calculated to be a significantly high relative risk of HCC development (HR, up to 20.1; adjusted HR, up to 7.3; all P < 0.05), whereas APRI was not (P = 0.168). The cumulative incidence of HCC development was significantly different among three risk groups (P < 0.001, log-rank test). CONCLUSIONS: This study suggests that GPR can be used as a noninvasive marker to assess the risk of HCC development in CHB patients.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherBlackwell Scientific Publications-
dc.relation.isPartOfJournal of Gastroenterology and Hepatology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBiomarkers, Tumor/blood*-
dc.subject.MESHCarcinoma, Hepatocellular/diagnosis*-
dc.subject.MESHCarcinoma, Hepatocellular/etiology*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHepatitis B, Chronic/complications*-
dc.subject.MESHHumans-
dc.subject.MESHLiver Neoplasms/diagnosis*-
dc.subject.MESHLiver Neoplasms/etiology*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPlatelet Count*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHTime Factors-
dc.subject.MESHgamma-Glutamyltransferase/blood*-
dc.titleGamma-glutamyl transpeptidase-to-platelet ratio is an independent predictor of hepatitis B virus-related liver cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorYong Eun Park-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorKwang‐Hyub Han-
dc.contributor.googleauthorSojung Han-
dc.contributor.googleauthorMi Young Jeon-
dc.contributor.googleauthorJa Yoon Heo-
dc.contributor.googleauthorKijun Song-
dc.contributor.googleauthorSeung Up Kim-
dc.identifier.doi10.1111/jgh.13653-
dc.contributor.localIdA00385-
dc.contributor.localIdA00487-
dc.contributor.localIdA00654-
dc.contributor.localIdA04571-
dc.contributor.localIdA01675-
dc.contributor.localIdA02226-
dc.contributor.localIdA05405-
dc.contributor.localIdA04268-
dc.contributor.localIdA05438-
dc.relation.journalcodeJ01417-
dc.identifier.eissn1440-1746-
dc.identifier.pmid27859587-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/abs/10.1111/jgh.13653-
dc.subject.keywordchronic hepatitis B-
dc.subject.keywordgamma-glutamyl transpeptidase-to-platelet ratio-
dc.subject.keywordhepatitis B virus-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordliver fibrosis-
dc.subject.keywordnoninvasive predictor-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Yong Eun-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameJeon, Mi Young-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameHan, Sojung-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.contributor.affiliatedAuthorKim, Beom Kyung-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Yong Eun-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorJeon, Mi Young-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorHan, Sojung-
dc.citation.volume32-
dc.citation.number6-
dc.citation.startPage1221-
dc.citation.endPage1229-
dc.identifier.bibliographicCitationJournal of Gastroenterology and Hepatology, Vol.32(6) : 1221-1229, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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