Cited 3 times in
Predictive factors of early distant brain failure after gamma knife radiosurgery alone in patients with brain metastases of non-small-cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | 김혜련 | - |
dc.contributor.author | 박용구 | - |
dc.contributor.author | 장원석 | - |
dc.contributor.author | 장진우 | - |
dc.contributor.author | 정현호 | - |
dc.contributor.author | 조병철 | - |
dc.date.accessioned | 2018-07-20T07:44:44Z | - |
dc.date.available | 2018-07-20T07:44:44Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0167-594X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160482 | - |
dc.description.abstract | The objective of this study was to elucidate the predictive factors for early distant brain failure in patients with brain metastases of non-small-cell lung cancer (NSCLC) who were treated with gamma knife radiosurgery (GKRS) without previous whole-brain radiotherapy (WBRT) or surgery. We retrospectively reviewed clinical and imaging data of 459 patients with brain metastases of NSCLC who underwent GKRS from June 2008 to December 2013. The primary end-point was early distant brain failure, defined as the detection of newly developed metastatic lesions on magnetic resonance imaging (MRI) 3 months after GKRS. Factors such as tumor pathology subtype, concurrent systemic chemotherapy, epidermal growth factor receptor (EGFR) mutation status, use of EGFR tyrosine kinase inhibitors (TKIs), systemic disease status, presence of a metastatic lesion only in delayed MRI, and volume and number of metastases were analyzed. There were no statistically significant differences with respect to pathologic subtype, concurrent systemic chemotherapy, EGFR mutation, and early distant brain failure. Patients treated with EGFR-TKIs (p = 0.004), with a stable systemic disease status (p = 0.028) and 3 or fewer brain lesions (p = 0.000) experienced a significantly lower incidence of early distant brain failure. This study suggests that GKRS alone could be considered for patients treated with EGFR-TKIs who have a stable systemic disease status and 3 or fewer brain lesions. WBRT should be considered for other patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | JOURNAL OF NEURO-ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Brain Neoplasms/diagnostic imaging | - |
dc.subject.MESH | Brain Neoplasms/radiotherapy* | - |
dc.subject.MESH | Brain Neoplasms/secondary* | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/diagnostic imaging | - |
dc.subject.MESH | Carcinoma, Non-Small-Cell Lung/pathology* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Lung Neoplasms/diagnostic imaging | - |
dc.subject.MESH | Lung Neoplasms/pathology* | - |
dc.subject.MESH | Magnetic Resonance Imaging | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Mutation/radiation effects | - |
dc.subject.MESH | Outcome Assessment (Health Care) | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Radiosurgery/adverse effects* | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/genetics | - |
dc.subject.MESH | Receptor, Epidermal Growth Factor/metabolism | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Young Adult | - |
dc.title | Predictive factors of early distant brain failure after gamma knife radiosurgery alone in patients with brain metastases of non-small-cell lung cancer | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Young Cheol Na | - |
dc.contributor.googleauthor | Hyun Ho Jung | - |
dc.contributor.googleauthor | Hye Ryun Kim | - |
dc.contributor.googleauthor | Byoung Chul Cho | - |
dc.contributor.googleauthor | Jin Woo Chang | - |
dc.contributor.googleauthor | Yong Gou Park | - |
dc.contributor.googleauthor | Won Seok Chang | - |
dc.identifier.doi | 10.1007/s11060-017-2373-4 | - |
dc.contributor.localId | A01166 | - |
dc.contributor.localId | A01578 | - |
dc.contributor.localId | A03454 | - |
dc.contributor.localId | A03484 | - |
dc.contributor.localId | A03775 | - |
dc.contributor.localId | A03822 | - |
dc.relation.journalcode | J01629 | - |
dc.identifier.eissn | 1573-7373 | - |
dc.identifier.pmid | 28074321 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs11060-017-2373-4 | - |
dc.subject.keyword | Brain metastases | - |
dc.subject.keyword | Non-small cell lung cancer | - |
dc.subject.keyword | Predictive factor | - |
dc.subject.keyword | Radiosurgery | - |
dc.contributor.alternativeName | Kim, Hye Ryun | - |
dc.contributor.alternativeName | Park, Yong Gou | - |
dc.contributor.alternativeName | Chang, Won Seok | - |
dc.contributor.alternativeName | Chang, Jin Woo | - |
dc.contributor.alternativeName | Jung, Hyun Ho | - |
dc.contributor.alternativeName | Cho, Byoung Chul | - |
dc.contributor.affiliatedAuthor | Kim, Hye Ryun | - |
dc.contributor.affiliatedAuthor | Park, Yong Gou | - |
dc.contributor.affiliatedAuthor | Chang, Won Seok | - |
dc.contributor.affiliatedAuthor | Chang, Jin Woo | - |
dc.contributor.affiliatedAuthor | Jung, Hyun Ho | - |
dc.contributor.affiliatedAuthor | Cho, Byoung Chul | - |
dc.citation.volume | 132 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 333 | - |
dc.citation.endPage | 340 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NEURO-ONCOLOGY, Vol.132(2) : 333-340, 2017 | - |
dc.identifier.rimsid | 43081 | - |
dc.type.rims | ART | - |
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