Cited 7 times in
Effects of Postoperative Radiotherapy on Leptomeningeal Carcinomatosis or Dural Metastasis after Resection of Brain Metastases in Breast Cancer Patients
DC Field | Value | Language |
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dc.contributor.author | 강석구 | - |
dc.contributor.author | 서창옥 | - |
dc.contributor.author | 장종희 | - |
dc.contributor.author | 정승연 | - |
dc.date.accessioned | 2018-07-20T07:44:18Z | - |
dc.date.available | 2018-07-20T07:44:18Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160475 | - |
dc.description.abstract | PURPOSE: In this retrospective study, we compared the incidence of leptomeningeal carcinomatosis or dural metastasis (LMCDM) in patients who received whole brain radiotherapy (WBRT), partial radiotherapy (PRT), or no radiotherapy (RT) following resection of brain metastases from breast cancer. MATERIALS AND METHODS: Fifty-one patients with breast cancer underwent surgical resection for newly diagnosed brain metastases in two institutions between March 2001 and March 2015. Among these, 34 received postoperative WBRT (n=24) or PRT (n=10) and 17 did not. RESULTS: With a median follow-up of 12.4 months (range, 2.3 to 83.6 months), 22/51 patients developed LMCDM at a median of 8.6 months (range, 4.8 to 51.2 months) after surgery. The 18-months LMCDM-free survival (LMCDM-FS) rates were 77.5%, 30.0%, and 13.6%, in the WBRT, PRT, and no RT groups, respectively (p=0.013). The presence of a tumor adjacent to cerebrospinal fluid flow and no systemic treatment after treatment for brain metastases were also associated with poor LMCDM-FS rate. Multivariate analysis showed that WBRT compared to PRT (p=0.009) and systemic treatment (p < 0.001) were independently associated with reduced incidence of LMCDM. CONCLUSION: WBRT improved LMCDM-FS rate after resection of brain metastases compared to PRT in breast cancer patients. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Brain Neoplasms/diagnosis | - |
dc.subject.MESH | Brain Neoplasms/secondary* | - |
dc.subject.MESH | Brain Neoplasms/therapy* | - |
dc.subject.MESH | Breast Neoplasms/pathology* | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods | - |
dc.subject.MESH | Meningeal Carcinomatosis/diagnosis | - |
dc.subject.MESH | Meningeal Carcinomatosis/secondary* | - |
dc.subject.MESH | Meningeal Carcinomatosis/therapy* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Postoperative Care | - |
dc.subject.MESH | Radiotherapy | - |
dc.subject.MESH | Receptor, ErbB-2 | - |
dc.subject.MESH | Recurrence | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Treatment Failure | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Effects of Postoperative Radiotherapy on Leptomeningeal Carcinomatosis or Dural Metastasis after Resection of Brain Metastases in Breast Cancer Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurosurgery | - |
dc.contributor.googleauthor | Boram Ha | - |
dc.contributor.googleauthor | Seung Yeun Chung | - |
dc.contributor.googleauthor | Yeon-Joo Kim | - |
dc.contributor.googleauthor | Ho-Shin Gwak | - |
dc.contributor.googleauthor | Jong Hee Chang | - |
dc.contributor.googleauthor | Sang Hyun Lee | - |
dc.contributor.googleauthor | In Hae Park | - |
dc.contributor.googleauthor | Keun Seok Lee | - |
dc.contributor.googleauthor | Seeyoun Lee | - |
dc.contributor.googleauthor | Tae Hyun Kim | - |
dc.contributor.googleauthor | Dae Yong Kim | - |
dc.contributor.googleauthor | Seok-Gu Kang | - |
dc.contributor.googleauthor | Chang-Ok Suh | - |
dc.identifier.doi | 10.4143/crt.2016.303 | - |
dc.contributor.localId | A00036 | - |
dc.contributor.localId | A01919 | - |
dc.contributor.localId | A03470 | - |
dc.contributor.localId | A05411 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.identifier.pmid | 27809457 | - |
dc.subject.keyword | Breast neoplasms | - |
dc.subject.keyword | Meningeal carcinomatosis | - |
dc.subject.keyword | Partial radiotherapy | - |
dc.subject.keyword | Whole brain radiotherapy | - |
dc.contributor.alternativeName | Kang, Seok Gu | - |
dc.contributor.alternativeName | Suh, Chang Ok | - |
dc.contributor.alternativeName | Chang, Jong Hee | - |
dc.contributor.alternativeName | Chung, Seung Yeun | - |
dc.contributor.affiliatedAuthor | Kang, Seok Gu | - |
dc.contributor.affiliatedAuthor | Suh, Chang Ok | - |
dc.contributor.affiliatedAuthor | Chang, Jong Hee | - |
dc.contributor.affiliatedAuthor | Chung, Seung Yeun | - |
dc.citation.volume | 49 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 748 | - |
dc.citation.endPage | 758 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.49(3) : 748-758, 2017 | - |
dc.identifier.rimsid | 42311 | - |
dc.type.rims | ART | - |
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