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Liver fibrosis assessed with transient elastography is an independent risk factor for ischemic stroke

DC Field Value Language
dc.contributor.author김광준-
dc.contributor.author김도영-
dc.contributor.author김범경-
dc.contributor.author김승업-
dc.contributor.author김영대-
dc.contributor.author박준용-
dc.contributor.author송동범-
dc.contributor.author안상훈-
dc.contributor.author유준상-
dc.contributor.author한광협-
dc.contributor.author허지회-
dc.date.accessioned2018-07-20T07:43:49Z-
dc.date.available2018-07-20T07:43:49Z-
dc.date.issued2017-
dc.identifier.issn0021-9150-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160469-
dc.description.abstractBACKGROUND AND AIMS: The relationship between liver fibrosis and the occurrence of ischemic stroke is unknown. We investigated the correlation between liver fibrosis assessed with transient elastography (TE) and the risk of ischemic stroke. METHODS: Between April 2013 and August 2014, patients with acute ischemic stroke and subjects who underwent a health check-up were included in the study. Liver fibrotic burden was assessed with TE in all participants. The degree of liver fibrosis was compared between groups by using various multiple logistic regression models and propensity-score matched analyses. RESULTS: Two hundred ninety-five patients with ischemic stroke (stroke group) and 1942 subjects with health check-up (control group) were included. The mean liver stiffness (LS) on TE (5.6 vs. 4.1 kPa) and the proportion of significant fibrosis (>8 kPa) (9.2% vs. 1.8%) were significantly higher in the stroke than in the control group (all p<0.05). These trends were observed regardless of body mass index, the degree of hepatic steatosis, and metabolic syndrome (all p<0.05). The adjusted odds ratio (OR) for ischemic stroke was 1.268 (95% confidence intervals [CI] 1.183-1.358) per 1 kPa increase and 12.033 (95% CI 5.180-27.948) for significant fibrosis, compared with no fibrosis (all p < 0.05). Propensity-score matched analysis also confirmed that liver fibrosis was independently associated with the risk of ischemic stroke (OR 1.804 [95% CI 1.461-2.230] per 1 kPa increase, 13.184 [95% CI 3.127-55.645] for significant fibrosis, compared with no fibrosis; all p<0.001). CONCLUSIONS: The degree of liver fibrosis, assessed with TE, was significantly associated with the risk of ischemic stroke.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfATHEROSCLEROSIS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcute Disease-
dc.subject.MESHBiopsy-
dc.subject.MESHBody Mass Index-
dc.subject.MESHBrain/diagnostic imaging-
dc.subject.MESHBrain Ischemia/diagnosis-
dc.subject.MESHBrain Ischemia/epidemiology-
dc.subject.MESHBrain Ischemia/etiology*-
dc.subject.MESHElasticity Imaging Techniques/methods*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHIncidence-
dc.subject.MESHLiver/diagnostic imaging*-
dc.subject.MESHLiver Cirrhosis/complications-
dc.subject.MESHLiver Cirrhosis/diagnostic imaging*-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPrognosis-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment*-
dc.subject.MESHRisk Factors-
dc.subject.MESHTomography, X-Ray Computed-
dc.titleLiver fibrosis assessed with transient elastography is an independent risk factor for ischemic stroke-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorDongbeom Song-
dc.contributor.googleauthorJi Hoe Heo-
dc.contributor.googleauthorJoonsang Yoo-
dc.contributor.googleauthorBeom Kyung Kim-
dc.contributor.googleauthorJun Yong Park-
dc.contributor.googleauthorDo Young Kim-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorKwang Joon Kim-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorYoung Dae Kim-
dc.identifier.doi10.1016/j.atherosclerosis.2017.02.005-
dc.contributor.localIdA00317-
dc.contributor.localIdA00385-
dc.contributor.localIdA00487-
dc.contributor.localIdA00654-
dc.contributor.localIdA00702-
dc.contributor.localIdA01675-
dc.contributor.localIdA02017-
dc.contributor.localIdA02226-
dc.contributor.localIdA02513-
dc.contributor.localIdA04268-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ00260-
dc.identifier.eissn1879-1484-
dc.identifier.pmid28222857-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0021915017300576-
dc.subject.keywordLiver stiffness-
dc.subject.keywordRisk factors-
dc.subject.keywordStroke-
dc.subject.keywordTransient elastography-
dc.contributor.alternativeNameKim, Kwang Joon-
dc.contributor.alternativeNameKim, Do Young-
dc.contributor.alternativeNameKim, Beom Kyung-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.alternativeNamePark, Jun Yong-
dc.contributor.alternativeNameSong, Dong Beom-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameYoo, Joon Sang-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameHeo, Ji Hoe-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.contributor.affiliatedAuthorKim, Do Young-
dc.contributor.affiliatedAuthorKim, Beom Kyung-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorKim, Young Dae-
dc.contributor.affiliatedAuthorPark, Jun Yong-
dc.contributor.affiliatedAuthorSong, Dong Beom-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorYoo, Joon Sang-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorHeo, Ji Hoe-
dc.citation.volume260-
dc.citation.startPage156-
dc.citation.endPage162-
dc.identifier.bibliographicCitationATHEROSCLEROSIS, Vol.260 : 156-162, 2017-
dc.identifier.rimsid42305-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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