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Thermo-sensitive assembly of the biomaterial REP reduces hematoma volume following collagenase-induced intracerebral hemorrhage in rats

Authors
 Joohyun Park  ;  Jong Youl Kim  ;  Seong-Kyoon Choi  ;  Jae Young Kim  ;  Jae Hwan Kim  ;  Won Bae Jeon  ;  Jong Eun Lee 
Citation
 NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Vol.13(6) : 1853-1862, 2017 
Journal Title
 NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 
ISSN
 1549-9634 
Issue Date
2017
MeSH
Animals ; Biocompatible Materials ; Cerebral Hemorrhage/drug therapy* ; Collagenases ; Disease Models, Animal* ; Hematoma/chemically induced ; Hematoma/pathology ; Hematoma/therapy* ; Male ; Microglia ; Neuroprotective Agents/therapeutic use* ; Peptide Fragments/therapeutic use* ; Rats ; Rats, Sprague-Dawley ; Temperature ; Thermodynamics ; Tropoelastin/administration & dosage* ; Tropoelastin/chemistry
Keywords
Elastin-like polypeptide ; Intracerebral hemorrhage ; Nanomaterial ; RGD-containing elastin-like polypeptide
Abstract
Intracerebral hemorrhage (ICH) frequently results in severe disabilities and high mortality. RGD-containing elastin-like polypeptide (REP), a modified elastin-like polypeptide (ELP), is a thermally responsive biopolymer. REP has high affinity for cells and is known to show non-immunotoxicity, -cytotoxicity, and -inflammatory responses. Here we found that administration of REP in the acute phase of the ICH rat model reduced the hematoma volume, decreased the number of activated microglia, attenuated the expression of von Willebrand Factor (vWF), and prevented the leakage of immunoglobulin G (IgG) into the cerebral parenchyma without any occlusion of intact microvessels. Therefore, the present data suggest that REP treatment could be a novel therapeutic strategy for attenuating the acute phase of ICH.
Files in This Item:
T201702400.pdf Download
DOI
10.1016/j.nano.2017.04.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Youl(김종열) ORCID logo https://orcid.org/0000-0002-8340-2894
Park, Joohyun(박주현) ORCID logo https://orcid.org/0000-0002-0897-4665
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160459
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