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Fatty liver associated with metabolic derangement in patients with chronic kidney disease: A controlled attenuation parameter study

DC FieldValueLanguage
dc.contributor.author강신욱-
dc.contributor.author김승업-
dc.contributor.author박정탁-
dc.contributor.author안상훈-
dc.contributor.author유태현-
dc.contributor.author이미솔-
dc.contributor.author한승혁-
dc.date.accessioned2018-07-20T07:43:06Z-
dc.date.available2018-07-20T07:43:06Z-
dc.date.issued2017-
dc.identifier.issn2211-9132-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160457-
dc.description.abstractBACKGROUND: Hepatic steatosis measured with controlled attenuation parameter (CAP) using transient elastography predicts metabolic syndrome in the general population. We investigated whether CAP predicted metabolic syndrome in chronic kidney disease patients. METHODS: CAP was measured with transient elastography in 465 predialysis chronic kidney disease patients (mean age, 57.5 years). RESULTS: The median CAP value was 239 (202-274) dB/m. In 195 (41.9%) patients with metabolic syndrome, diabetes mellitus was more prevalent (105 [53.8%] vs. 71 [26.3%], P < 0.001), with significantly increased urine albumin-to-creatinine ratio (184 [38-706] vs. 56 [16-408] mg/g Cr, P = 0.003), high sensitivity C-reactive protein levels (5.4 [1.4-28.2] vs. 1.7 [0.6-9.9] mg/L, P < 0.001), and CAP (248 [210-302] vs. 226 [196-259] dB/m, P < 0.001). In multiple linear regression analysis, CAP was independently related to body mass index (β = 0.742, P < 0.001), triglyceride levels (β = 2.034, P < 0.001), estimated glomerular filtration rate (β = 0.316, P = 0.001), serum albumin (β = 1.386, P < 0.001), alanine aminotransferase (β = 0.064, P = 0.029), and total bilirubin (β = -0.881, P = 0.009). In multiple logistic regression analysis, increased CAP was independently associated with increased metabolic syndrome risk (per 10 dB/m increase; odds ratio, 1.093; 95% confidence interval, 1.009-1.183; P = 0.029) even after adjusting for multiple confounding factors. CONCLUSION: Increased CAP measured with transient elastography significantly correlated with and could predict increased metabolic syndrome risk in chronic kidney disease patients.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherElsevier Korea-
dc.relation.isPartOfKIDNEY RESEARCH AND CLINICAL PRACTICE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleFatty liver associated with metabolic derangement in patients with chronic kidney disease: A controlled attenuation parameter study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorChang-Yun Yoon-
dc.contributor.googleauthorMisol Lee-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorHyunsun Lim-
dc.contributor.googleauthorTae Ik Chang-
dc.contributor.googleauthorYoun Kyung Kee-
dc.contributor.googleauthorSeung Gyu Han-
dc.contributor.googleauthorIn Mee Han-
dc.contributor.googleauthorYoung Eun Kwon-
dc.contributor.googleauthorKyoung Sook Park-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorJung Tak Park-
dc.contributor.googleauthorSeung Hyeok Han-
dc.contributor.googleauthorSang Hoon Ahn-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.identifier.doi10.23876/j.krcp.2017.36.1.48-
dc.contributor.localIdA00053-
dc.contributor.localIdA00654-
dc.contributor.localIdA01654-
dc.contributor.localIdA02226-
dc.contributor.localIdA02526-
dc.contributor.localIdA02771-
dc.contributor.localIdA04304-
dc.relation.journalcodeJ01942-
dc.identifier.eissn2211-9140-
dc.identifier.pmid28392997-
dc.subject.keywordChronic kidney disease-
dc.subject.keywordHepatic steatosis-
dc.subject.keywordMetabolic syndrome-
dc.subject.keywordTransient elastography-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Jung Tak-
dc.contributor.alternativeNameAhn, Sang Hoon-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameLee, Mi Sol-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Jung Tak-
dc.contributor.affiliatedAuthorAhn, Sang Hoon-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorLee, Mi Sol-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.citation.volume36-
dc.citation.number1-
dc.citation.startPage48-
dc.citation.endPage57-
dc.identifier.bibliographicCitationKIDNEY RESEARCH AND CLINICAL PRACTICE, Vol.36(1) : 48-57, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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