56 72

Cited 7 times in

The effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma

DC FieldValueLanguage
dc.contributor.author강지인-
dc.contributor.author김세주-
dc.contributor.author이승태-
dc.contributor.author최종락-
dc.date.accessioned2018-07-20T07:42:24Z-
dc.date.available2018-07-20T07:42:24Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160444-
dc.description.abstractTelomere length has been suggested to be a cellular marker for age-related diseases as well as psychosocial stress. The present study investigated whether telomere length is associated with post-traumatic stress disorder (PTSD) among veterans exposed to combat trauma in the Vietnam War. The potentially associated factors on cellular aging were considered. Korean male veterans with (n = 122) and without (n = 120) PTSD were included and leukocyte telomere length was measured with a quantitative PCR-based technique. As a whole, no significant difference in telomere length was found between PTSD and non-PTSD groups. In linear regression analysis stratified by trauma levels, among veterans exposed to severe combat (n = 45), PTSD status (B = -1.176, t = -2.259, p = 0.029), antidepressant use (B = 0.168, t = 2.528, p = 0.015), and education level (B = 0.019, t = 2.369, p = 0.023) affected telomere length. However, among veterans with light-to-moderate combat exposure (n = 197), only age (B = -0.007, t = -2.434, p = 0.016) and education level (B = 0.010, t = 2.295, p = 0.023) were associated with telomere length. In the Post-hoc analysis, antidepressant use was associated with longer telomere length in subjects exposed to severe combat. Our exploratory results suggest that PTSD status in combination with severe trauma may be associated with accelerated telomere shortening, and that antidepressant use may have a protective effect on telomere dynamics.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfScientific Reports-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Psychiatry-
dc.contributor.googleauthorTae Yong Kim-
dc.contributor.googleauthorSe Joo Kim-
dc.contributor.googleauthorJong Rak Choi-
dc.contributor.googleauthorSeung-Tae Lee-
dc.contributor.googleauthorJieun Kim-
dc.contributor.googleauthorIn Sik Hwang-
dc.contributor.googleauthorHae Gyung Chung-
dc.contributor.googleauthorJin Hee Choi-
dc.contributor.googleauthorHae Won Kim-
dc.contributor.googleauthorSe Hyun Kim-
dc.contributor.googleauthorJee In Kang-
dc.identifier.doi10.1038/s41598-017-04682-w-
dc.contributor.localIdA04920-
dc.contributor.localIdA00084-
dc.contributor.localIdA00604-
dc.contributor.localIdA04627-
dc.contributor.localIdA04182-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid28663541-
dc.contributor.alternativeNameKang, Jee In-
dc.contributor.alternativeNameKim, Se Joo-
dc.contributor.alternativeNameLee, Seung-Tae-
dc.contributor.alternativeNameChoi, Jong Rak-
dc.contributor.affiliatedAuthorKim, Hae Won-
dc.contributor.affiliatedAuthorKang, Jee In-
dc.contributor.affiliatedAuthorKim, Se Joo-
dc.contributor.affiliatedAuthorLee, Seung-Tae-
dc.contributor.affiliatedAuthorChoi, Jong Rak-
dc.citation.volume7-
dc.citation.number1-
dc.citation.startPage4375-
dc.identifier.bibliographicCitationScientific Reports, Vol.7(1) : 4375, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.