Cited 45 times in
Early Oncologic Failure after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium
DC Field | Value | Language |
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dc.contributor.author | 나군호 | - |
dc.date.accessioned | 2018-07-20T07:41:50Z | - |
dc.date.available | 2018-07-20T07:41:50Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0022-5347 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160433 | - |
dc.description.abstract | PURPOSE: We sought to investigate the prevalence and variables associated with early oncologic failure. MATERIALS AND METHODS: We retrospectively reviewed the IRCC (International Radical Cystectomy Consortium) database of patients who underwent robot-assisted radical cystectomy since 2003. The final cohort comprised a total of 1,894 patients from 23 institutions in 11 countries. Early oncologic failure was defined as any disease relapse within 3 months of robot-assisted radical cystectomy. All institutions were surveyed for the pneumoperitoneum pressure used, breach of oncologic surgical principles, and techniques of specimen and lymph node removal. A multivariate model was fit to evaluate predictors of early oncologic failure. The Kaplan-Meier method was applied to depict disease specific and overall survival, and Cox proportional regression analysis was used to evaluate predictors of disease specific and overall survival. RESULTS: A total of 305 patients (22%) experienced disease relapse, which was distant in 220 (16%), local recurrence in 154 (11%), peritoneal carcinomatosis in 17 (1%) and port site recurrence in 5 (0.4%). Early oncologic failure developed in 71 patients (5%) at a total of 10 institutions. The incidence of early oncologic failure decreased from 10% in 2006 to 6% in 2015. On multivariate analysis the presence of any complication (OR 2.87, 95% CI 1.38-5.96, p = 0.004), pT3 or greater disease (OR 3.73, 95% CI 2.00-6.97, p <0.001) and nodal involvement (OR 2.14, 95% CI 1.21-3.80, p = 0.008) was a significant predictor of early oncologic failure. Patients with early oncologic failure demonstrated worse disease specific and overall survival (23% and 13%, respectively) at 1 and 3 years compared to patients who experienced later or no recurrences (log rank p <0.001). CONCLUSIONS: The incidence of early oncologic failure following robot-assisted radical cystectomy has decreased with time. Disease related rather than technical related factors have a major role in early oncologic failure after robot-assisted radical cystectomy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Early Oncologic Failure after Robot-Assisted Radical Cystectomy: Results from the International Robotic Cystectomy Consortium | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Urology | - |
dc.contributor.googleauthor | Ahmed A. Hussein | - |
dc.contributor.googleauthor | Matthias Saar | - |
dc.contributor.googleauthor | Paul R. May | - |
dc.contributor.googleauthor | Carl J. Wijburg | - |
dc.contributor.googleauthor | Lee Richstone | - |
dc.contributor.googleauthor | Andrew Wagner | - |
dc.contributor.googleauthor | Timothy Wilson | - |
dc.contributor.googleauthor | Bertram Yuh | - |
dc.contributor.googleauthor | Joan Palou Redorta | - |
dc.contributor.googleauthor | Prokar Dasgupta | - |
dc.contributor.googleauthor | Mohammad Shamim Khan | - |
dc.contributor.googleauthor | Mani Menon | - |
dc.contributor.googleauthor | James O. Peabody | - |
dc.contributor.googleauthor | Abolfazl Hosseini | - |
dc.contributor.googleauthor | Franco Gaboardi | - |
dc.contributor.googleauthor | Alexandre Mottrie | - |
dc.contributor.googleauthor | Koon-ho Rha | - |
dc.contributor.googleauthor | Ashok Hemal | - |
dc.contributor.googleauthor | Michael Stockle | - |
dc.contributor.googleauthor | John Kelly | - |
dc.contributor.googleauthor | Thomas J. Maatman | - |
dc.contributor.googleauthor | Abdullah Erdem Canda | - |
dc.contributor.googleauthor | Peter Wiklund | - |
dc.contributor.googleauthor | Khurshid A. Gur | - |
dc.identifier.doi | 10.1016/j.juro.2016.12.048 | - |
dc.contributor.localId | A01227 | - |
dc.relation.journalcode | J01921 | - |
dc.identifier.eissn | 1527-3792 | - |
dc.identifier.pmid | 27993668 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0022534716319851 | - |
dc.subject.keyword | cystectomy | - |
dc.subject.keyword | local | - |
dc.subject.keyword | neoplasm recurrence | - |
dc.subject.keyword | robotic surgical procedures | - |
dc.subject.keyword | treatment failure | - |
dc.subject.keyword | urinary bladder neoplasms | - |
dc.contributor.alternativeName | Rha, Koon Ho | - |
dc.contributor.affiliatedAuthor | Rha, Koon Ho | - |
dc.citation.volume | 197 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1427 | - |
dc.citation.endPage | 1436 | - |
dc.identifier.bibliographicCitation | JOURNAL OF UROLOGY, Vol.197(6) : 1427-1436, 2017 | - |
dc.identifier.rimsid | 40602 | - |
dc.type.rims | ART | - |
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