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Lysyl oxidase-like 2 is expressed in kidney tissue and is associated with the progression of tubulointerstitial fibrosis

DC Field Value Language
dc.contributor.author신재일-
dc.contributor.author임범진-
dc.contributor.author정현주-
dc.contributor.author최훈영-
dc.contributor.author최성은-
dc.date.accessioned2018-07-20T07:41:20Z-
dc.date.available2018-07-20T07:41:20Z-
dc.date.issued2017-
dc.identifier.issn1791-2997-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160422-
dc.description.abstractTubulointerstitial fibrosis is a common end point of chronic kidney diseases, and preventing its progression is key to avoiding renal failure. Transforming growth factor‑β (TGF‑β) and associated molecules promote tubulointerstitial fibrosis; however, effective therapies targeting these molecules have yet to be developed. Lysyl oxidase‑like 2 (LOXL2), which is involved in invasive growth and metastasis of malignant neoplasms, has recently been reported to serve a key role in hepatic and pulmonary fibrosis. However, little is currently known regarding LOXL2 expression in the kidney and its involvement in tubulointerstitial fibrosis. The present study evaluated LOXL2 expression in human and mouse kidney tissues, as well as in cultured renal cells. LOXL2 protein expression was detected in glomerular capillary loops and tubular epithelial cells in human and mouse kidneys. Glomerular LOXL2 was localized to the cytoplasm of podocytes, as determined by double immunofluorescence microscopy using a podocyte marker (synaptopodin). This result was supported by western blot analysis, which demonstrated that LOXL2 protein expression is present in cultured human podocytes and HK‑2 human proximal tubular cells. In addition, the mRNA and protein expression levels of LOXL2 were higher in a mouse model of tubulointerstitial fibrosis compared with in control mice. In addition, immunohistochemistry results demonstrated that LOXL2 is present in the fibrous interstitium and infiltrating mononuclear cells in a mouse model of tubulointerstitial fibrosis. The present study demonstrated that LOXL2 is expressed in compartments of renal tissue, where it appears to contribute to the progression of tubulointerstitial fibrosis.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherD. A. Spandidos-
dc.relation.isPartOfMOLECULAR MEDICINE REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAmino Acid Oxidoreductases/analysis-
dc.subject.MESHAmino Acid Oxidoreductases/genetics-
dc.subject.MESHAnimals-
dc.subject.MESHCell Line-
dc.subject.MESHDisease Progression-
dc.subject.MESHFibrosis-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHHumans-
dc.subject.MESHKidney/metabolism-
dc.subject.MESHKidney/pathology-
dc.subject.MESHKidney Glomerulus/metabolism-
dc.subject.MESHKidney Glomerulus/pathology-
dc.subject.MESHKidney Tubules/metabolism-
dc.subject.MESHKidney Tubules/pathology-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHPodocytes/metabolism-
dc.subject.MESHPodocytes/pathology-
dc.subject.MESHRenal Insufficiency, Chronic/genetics-
dc.subject.MESHRenal Insufficiency, Chronic/pathology-
dc.titleLysyl oxidase-like 2 is expressed in kidney tissue and is associated with the progression of tubulointerstitial fibrosis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorSUNG‑EUN CHOI-
dc.contributor.googleauthorNARA JEON-
dc.contributor.googleauthorHOON YOUNG CHOI-
dc.contributor.googleauthorJAE IL SHIN-
dc.contributor.googleauthorHYEON JOO JEONG-
dc.contributor.googleauthorBEOM JIN LIM-
dc.identifier.doi10.3892/mmr.2017.6918-
dc.contributor.localIdA02142-
dc.contributor.localIdA03363-
dc.contributor.localIdA03771-
dc.contributor.localIdA04226-
dc.relation.journalcodeJ02261-
dc.identifier.eissn1791-3004-
dc.identifier.pmid28677767-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.alternativeNameLim, Beom Jin-
dc.contributor.alternativeNameJeong, Hyeon Joo-
dc.contributor.alternativeNameChoi, Hoon Young-
dc.contributor.affiliatedAuthorShin, Jae Il-
dc.contributor.affiliatedAuthorLim, Beom Jin-
dc.contributor.affiliatedAuthorJeong, Hyeon Joo-
dc.contributor.affiliatedAuthorChoi, Hoon Young-
dc.citation.volume16-
dc.citation.number3-
dc.citation.startPage2477-
dc.citation.endPage2482-
dc.identifier.bibliographicCitationMOLECULAR MEDICINE REPORTS, Vol.16(3) : 2477-2482, 2017-
dc.identifier.rimsid39801-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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