Cited 3 times in
Expression of Autophagy-Related Proteins in Hürthle Cell Neoplasm Is Different from That in Follicular Neoplasm
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 김혜민 | - |
dc.contributor.author | 차윤진 | - |
dc.date.accessioned | 2018-07-20T07:41:04Z | - |
dc.date.available | 2018-07-20T07:41:04Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0278-0240 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160418 | - |
dc.description.abstract | PURPOSE: We aimed to evaluate expression of autophagy-related proteins in Hürthle cell neoplasm (HCN) and follicular neoplasm (FN) and assess the clinical implications. METHODS: 265 FNs (112 follicular carcinomas and 153 follicular adenomas) and 108 HCNs (27 Hürthle cell carcinomas and 81 Hürthle cell adenomas) were made into a tissue microarray. Immunohistochemical staining and Western blot for autophagy-related proteins (beclin-1, light chain (LC) 3A, LC3B, p62, and BNIP3) were performed, and the results were statistically analyzed. RESULTS: A higher expression rate of beclin-1, LC3B, p62, and BNIP3 was found in HCN than in FN (P < 0.001). The expression rate of beclin-1, LC3B, p62, and BNIP3 was the highest in HCCs followed by HCAs, FCs, and FAs in that order (P < 0.001). HCCs were positive for the largest number of autophagy-related proteins followed by HCAs, FCs, and FAs (P < 0.001), and most of the positive markers identified in HCCs were the high autophagy type (P < 0.001), defined by positive staining for three or more of the five autophagy-related proteins. CONCLUSION: The autophagy-related proteins, beclin-1, LC3A, LC3B, p62, and BNIP3, were more frequently expressed in HCNs than in FNs, and HCCs showed the highest expression rate. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Hindawi Pub. Corp. | - |
dc.relation.isPartOf | DISEASE MARKERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenoma/metabolism* | - |
dc.subject.MESH | Adenoma/pathology | - |
dc.subject.MESH | Adenoma, Oxyphilic/metabolism* | - |
dc.subject.MESH | Adenoma, Oxyphilic/pathology | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Autophagy* | - |
dc.subject.MESH | Beclin-1/genetics | - |
dc.subject.MESH | Beclin-1/metabolism | - |
dc.subject.MESH | Biomarkers, Tumor/genetics | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Carcinoma/metabolism* | - |
dc.subject.MESH | Carcinoma/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Membrane Proteins/genetics | - |
dc.subject.MESH | Membrane Proteins/metabolism | - |
dc.subject.MESH | Microtubule-Associated Proteins/genetics | - |
dc.subject.MESH | Microtubule-Associated Proteins/metabolism | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Proto-Oncogene Proteins/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins/metabolism | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc/genetics | - |
dc.subject.MESH | Proto-Oncogene Proteins c-myc/metabolism | - |
dc.subject.MESH | Thyroid Neoplasms/metabolism* | - |
dc.subject.MESH | Thyroid Neoplasms/pathology | - |
dc.title | Expression of Autophagy-Related Proteins in Hürthle Cell Neoplasm Is Different from That in Follicular Neoplasm | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Hye Min Kim | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1155/2017/1372387 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A04553 | - |
dc.contributor.localId | A04001 | - |
dc.relation.journalcode | J00743 | - |
dc.identifier.eissn | 1875-8630 | - |
dc.identifier.pmid | 28819333 | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Kim, Hye Min | - |
dc.contributor.alternativeName | Cha, Yoon Jin | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Kim, Hye Min | - |
dc.contributor.affiliatedAuthor | Cha, Yoon Jin | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 2017 | - |
dc.citation.startPage | 1372387 | - |
dc.identifier.bibliographicCitation | DISEASE MARKERS, Vol.2017 : 1372387, 2017 | - |
dc.identifier.rimsid | 39797 | - |
dc.type.rims | ART | - |
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