Cited 24 times in
Risk of Gonadoblastoma Development in Patients with Turner Syndrome with Cryptic Y Chromosome Material
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 권아름 | - |
dc.contributor.author | 김호성 | - |
dc.contributor.author | 채현욱 | - |
dc.date.accessioned | 2018-07-20T07:39:54Z | - |
dc.date.available | 2018-07-20T07:39:54Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1868-8497 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160397 | - |
dc.description.abstract | Current guidelines recommend that testing for Y chromosome material should be performed only in patients with Turner syndrome harboring a marker chromosome and exhibiting virilization in order to detect individuals who are at high risk of gonadoblastoma. However, cryptic Y chromosome material is suggested to be a risk factor for gonadoblastoma in patients with Turner syndrome. Here, we aimed to estimate the frequency of cryptic Y chromosome material in patients with Turner syndrome and determine whether Y chromosome material increased the risk for development of gonadoblastoma. A total of 124 patients who were diagnosed with Turner syndrome by conventional cytogenetic techniques underwent additional molecular analysis to detect cryptic Y chromosome material. In addition, patients with Turner syndrome harboring Y chromosome cell lines had their ovaries removed prophylactically. Finally, we assessed the occurrence of gonadoblastoma in patients with Turner syndrome. Molecular analysis demonstrated that 10 patients had Y chromosome material among 118 patients without overt Y chromosome (8.5%). Six patients with overt Y chromosome and four patients with cryptic Y chromosome material underwent oophorectomy. Histopathological analysis revealed that the occurrence of gonadoblastoma in the total group was 2.4%, and gonadoblastoma occurred in one of six patients with an overt Y chromosome (16.7%) and 2 of 10 patients with cryptic Y chromosome material (20.0%). The risk of developing gonadoblastoma in patients with cryptic Y chromosome material was similar to that in patients with overt Y chromosome. Therefore, molecular screening for Y chromosome material should be recommended for all patients with Turner syndrome to detect individuals at a high risk of gonadoblastoma and to facilitate proper management of the disease. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | United States | - |
dc.publisher | 1868-8500 | - |
dc.relation.isPartOf | HORMONES & CANCER | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Chromosomes, Human, Y/genetics* | - |
dc.subject.MESH | Cytogenetic Analysis* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gonadoblastoma/diagnosis | - |
dc.subject.MESH | Gonadoblastoma/genetics* | - |
dc.subject.MESH | Gonadoblastoma/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Karyotype Risk Factors | - |
dc.subject.MESH | Turner Syndrome/diagnosis | - |
dc.subject.MESH | Turner Syndrome/genetics* | - |
dc.subject.MESH | Turner Syndrome/pathology | - |
dc.title | Risk of Gonadoblastoma Development in Patients with Turner Syndrome with Cryptic Y Chromosome Material | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pediatrics | - |
dc.contributor.googleauthor | Ahreum Kwon | - |
dc.contributor.googleauthor | Sei Eun Hyun | - |
dc.contributor.googleauthor | Mo Kyung Jung | - |
dc.contributor.googleauthor | Hyun Wook Chae | - |
dc.contributor.googleauthor | Woo Jung Lee | - |
dc.contributor.googleauthor | Tae Hyuk Kim | - |
dc.contributor.googleauthor | Duk Hee Kim | - |
dc.contributor.googleauthor | Ho-Seong Kim | - |
dc.identifier.doi | 10.1007/s12672-017-0291-8 | - |
dc.contributor.localId | A00228 | - |
dc.contributor.localId | A01184 | - |
dc.contributor.localId | A04026 | - |
dc.relation.journalcode | J03344 | - |
dc.identifier.eissn | 1868-8500 | - |
dc.identifier.pmid | 28349385 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs12672-017-0291-8 | - |
dc.contributor.alternativeName | Kwon, Ah Reum | - |
dc.contributor.alternativeName | Kim, Ho Seong | - |
dc.contributor.alternativeName | Chae, Hyun Wook | - |
dc.contributor.affiliatedAuthor | Kwon, Ah Reum | - |
dc.contributor.affiliatedAuthor | Kim, Ho Seong | - |
dc.contributor.affiliatedAuthor | Chae, Hyun Wook | - |
dc.citation.volume | 8 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 166 | - |
dc.citation.endPage | 173 | - |
dc.identifier.bibliographicCitation | HORMONES & CANCER, Vol.8(3) : 166-173, 2017 | - |
dc.identifier.rimsid | 44114 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.