Cited 42 times in
The effect of intraoperative dexmedetomidine on acute kidney injury after pediatric congenital heart surgery: A prospective randomized trial.
DC Field | Value | Language |
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dc.contributor.author | 김지영 | - |
dc.date.accessioned | 2018-07-20T07:39:09Z | - |
dc.date.available | 2018-07-20T07:39:09Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160382 | - |
dc.description.abstract | BACKGROUND: Dexmedetomidine has been reported to have a renal protective effect after adult open heart surgery. The authors hypothesized that intraoperative infusion of dexmedetomidine would attenuate the decrease in renal function after pediatric open heart surgery. METHODS: Twenty-nine pediatric patients (1-6 years) scheduled for atrial or ventricular septal defect repair were randomly assigned to receive either continuous infusion of normal saline (control group, n = 14) or dexmedetomidine (a bolus dose of 0.5 μg/kg and then an infusion of 0.5 μg/kg/h) (dexmedetomidine group, n = 15) from anesthesia induction to the end of cardiopulmonary bypass. Serum creatinine (Scr) was measured before surgery (T0), 10 minutes after anesthesia induction (T1), 5 minutes after cardiopulmonary bypass weaning (T2), 2 hours after T2 (T3), and after postoperative day 1 (POD1) and postoperative day 2 (POD2) and estimated glomerular filtration rates (eGFRs) were calculated. Renal biomarkers were measured at T1, T2, and T3. Acute kidney injury (AKI) was defined as an absolute increase in Scr of ≥ 0.3 mg/dL or a percent increase in Scr of ≥50%. RESULTS: The incidence of AKI during the perioperative period was significantly higher in the control group than in the dexmedetomidine group (64% [9/14] vs 27% [4/15], P = .042). eGFR was significantly lower in the control group than in the dexmedetomidine group at T2 (72.6 ± 15.1 vs 83.9 ± 13.5, P = .044) and T3 (73.4 ± 15.4 vs 86.7 ± 15.9, P = .03). CONCLUSION: Intraoperative infusion of dexmedetomidine may reduce the incidence of AKI and suppress post-bypass eGFR decline. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Kidney Injury/epidemiology | - |
dc.subject.MESH | Acute Kidney Injury/etiology | - |
dc.subject.MESH | Acute Kidney Injury/physiopathology | - |
dc.subject.MESH | Acute Kidney Injury/prevention & control | - |
dc.subject.MESH | Biomarkers/metabolism | - |
dc.subject.MESH | Cardiopulmonary Bypass | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Child, Preschool | - |
dc.subject.MESH | Dexmedetomidine/administration & dosage | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glomerular Filtration Rate/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Incidence | - |
dc.subject.MESH | Infant | - |
dc.subject.MESH | Intraoperative Care | - |
dc.subject.MESH | Kidney/drug effects | - |
dc.subject.MESH | Kidney/physiopathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Postoperative Complications/epidemiology | - |
dc.subject.MESH | Postoperative Complications/physiopathology | - |
dc.subject.MESH | Postoperative Complications/prevention & control | - |
dc.subject.MESH | Protective Agents/administration & dosage | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | The effect of intraoperative dexmedetomidine on acute kidney injury after pediatric congenital heart surgery: A prospective randomized trial. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Youn Yi Jo | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Ji Yeon Lee | - |
dc.contributor.googleauthor | Chang Hu Choi | - |
dc.contributor.googleauthor | Young Jin Chang | - |
dc.contributor.googleauthor | Hyun Jeong Kwak | - |
dc.identifier.doi | 10.1097/MD.0000000000007480 | - |
dc.contributor.localId | A00977 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 28700489 | - |
dc.contributor.alternativeName | Kim, Ji Young | - |
dc.contributor.affiliatedAuthor | Kim, Ji Young | - |
dc.citation.volume | 96 | - |
dc.citation.number | 28 | - |
dc.citation.startPage | e7480 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.96(28) : e7480, 2017 | - |
dc.identifier.rimsid | 43541 | - |
dc.type.rims | ART | - |
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