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Expression of DNA methylation-related proteins in invasive lobular carcinoma of breast: comparison to invasive ductal carcinoma
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 김혜민 | - |
dc.contributor.author | 차윤진 | - |
dc.date.accessioned | 2018-07-20T07:35:36Z | - |
dc.date.available | 2018-07-20T07:35:36Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0213-3911 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160318 | - |
dc.description.abstract | PURPOSE: We aimed to compare the expression of DNA methylation-related proteins in invasive lobular carcinoma (ILC) of breast with those of invasive ductal carcinoma (IDC) of breast and to assess its potential clinical application. METHODS: Immunohistochemical staining of DNS methylation-related proteins (5-meC, DNMT1, DNMT3B and ISL-1) was applied to tissue microarrays generated from 108 ILCs and 203 IDCs. Protein expression and its correlation with clinicopatholgic variables were statistically analyzed. RESULTS: ISL-1 and DNMT3B were highly expressed in ILC (p<0.001) and tumoral 5-meC was highly expressed in IDC (p=0.006). DNMT1 (p<0.001) showed higher expression rate in luminal A type ILC. ISL-1 and DNMT3B showed higher expression rate in both luminal A type and luminal B type of ILC (p<0.05). In IDC, tumoral 5-meC commonly showed high positive (p=0.039). On univariate analysis, shorter disease free survival of ILC was associated with DNMT1 high positivity (p=0.001) and ISL-1 positivity (p=0.018). CONCLUSION: DNA methylation-related proteins are differentially expressed in ILC and IDC, and DNMT1, DNMT3B and ISL-1 show high expression rate in ILC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Histology and Histopathology | - |
dc.relation.isPartOf | HISTOLOGY AND HISTOPATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/metabolism* | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/pathology | - |
dc.subject.MESH | Carcinoma, Lobular/metabolism* | - |
dc.subject.MESH | Carcinoma, Lobular/pathology | - |
dc.subject.MESH | DNA Methylation* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.title | Expression of DNA methylation-related proteins in invasive lobular carcinoma of breast: comparison to invasive ductal carcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | Yoon Jin Cha | - |
dc.contributor.googleauthor | Hye Min Kim | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.14670/HH-11-873 | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A04553 | - |
dc.contributor.localId | A04001 | - |
dc.relation.journalcode | J00993 | - |
dc.identifier.eissn | 1699-5848 | - |
dc.identifier.pmid | 28111737 | - |
dc.identifier.url | http://www.hh.um.es/Abstracts/Vol_32/32_11/32_11_1175.htm | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Kim, Hye Min | - |
dc.contributor.alternativeName | Cha, Yoon Jin | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Kim, Hye Min | - |
dc.contributor.affiliatedAuthor | Cha, Yoon Jin | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 32 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1175 | - |
dc.citation.endPage | 1185 | - |
dc.identifier.bibliographicCitation | HISTOLOGY AND HISTOPATHOLOGY, Vol.32(11) : 1175-1185, 2017 | - |
dc.identifier.rimsid | 40979 | - |
dc.type.rims | ART | - |
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