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The effects of fatty acid composition on cardiac hypertrophy and function in mouse models of diet-induced obesity

 Son Nguyen  ;  Dan Shao  ;  Loreta C. Tomasi  ;  Alyssa Braun  ;  Ana Barbosa Marcondes de Mattos  ;  Yong Seon Choi  ;  Outi Villet  ;  Nathan Roe  ;  Carliana R. Halterman  ;  Rong Tian  ;  Stephen C. Kolwicz Jr 
 Journal of Nutritional Biochemistry, Vol.46 : 137-142, 2017 
Journal Title
 Journal of Nutritional Biochemistry 
Issue Date
Adiposity ; Animals ; Body Weight ; Cardiomegaly/etiology* ; Diet, High-Fat/adverse effects ; Diet, Western/adverse effects* ; Disease Models, Animal ; Fatty Acids/adverse effects* ; Fatty Acids/analysis ; Fatty Acids/chemistry* ; Gas Chromatography-Mass Spectrometry ; Lipids/blood ; Male ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Obesity/complications ; Obesity/etiology*
Cardiomyopathy ; Fatty acid profiling ; Lipid metabolism ; Lipid overload ; Mouse strain
High-fat diets (HFDs) are used frequently to study the development of cardiac dysfunction in animal models of obesity and diabetes. However, impairment in systolic function, often reported as declining ejection fraction, may not consistently occur in a given time frame which could be contributable to a variety of factors within the experimental design. One major factor may be the amounts of saturated and unsaturated fatty acids (FAs) that are present in the diet. To determine whether the FA content and composition were critical determinants in the development of cardiac dysfunction in response to high-fat feeding, we fed adult, male mice Western diet (45% fat, 60% saturated), Surwit diet (60% fat, 90% saturated), milk-fat-based diet (60% fat, 60% saturated) or high-fat Western diet (HFWD, 60% fat, 32% saturated) for 12 weeks. We report that neither the amount of total fat nor the ratio of saturated to unsaturated FAs in the diets differentially affects body weight and adiposity in mice. In addition, no evidence of systolic dysfunction is present after 12 weeks. Interestingly, the HFWD, with equal parts saturated, monounsaturated and polyunsaturated FAs, induces mild cardiac hypertrophy and diastolic dysfunction after 12 weeks, which coincides with elevated serum levels of arachidonic acid. Our results suggest that the dietary FA content and composition may be a primary determinant of diastolic, but not systolic, dysfunction in animal models of diet-induced obesity.
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1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Choi, Yong Seon(최용선) ORCID logo https://orcid.org/0000-0002-5348-864X
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