Cited 6 times in
Intralipid Restoration of Myocardial Contractions Following Bupivacaine-Induced Asystole: Concentration- and Time-Dependence In Vitro
DC Field | Value | Language |
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dc.contributor.author | 민나현 | - |
dc.contributor.author | 박윤곤 | - |
dc.date.accessioned | 2018-07-20T07:31:12Z | - |
dc.date.available | 2018-07-20T07:31:12Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0003-2999 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160247 | - |
dc.description.abstract | BACKGROUND: The concentration- and time-response relationships of lipid emulsion (LE; Intralipid) on the recovery of myocardial contractility following bupivacaine (BPV)-induced asystole are poorly defined. METHODS: After achieving asystole by 500-μM BPV, varied concentrations of LE were applied to determine the recovery of stimulated contractile responses and contractions in the cardiac tissues of guinea pigs at a 1.2-Hz stimulation rate. These experiments were performed with LE in either a recirculating (2%-16%) or washout (nonrecirculating) condition (0.05%-12%) for 60 minutes. The effect of LE itself (0.05%-12%) was examined. Oxfenicine was used to evaluate the metabolic action of LE to reverse asystole. BPV concentrations in solution and myocardial tissues were measured. RESULTS: In the recirculation condition, partial recovery of contractile forces was observed for 60 minutes at 4%, 8%, and 12% LE. A contracture followed after exposure to 16% LE in some asystolic muscles. In the washout experiments, following asystole, LE (0.05%-12%) had no effect on the recovery time of the first and regular contractile responses. LE (0.1%-8%) restored contractility to baseline levels after 45 minutes; partial recovery was shown with lower (0.05%) and higher (12%) concentrations. Oxfenicine did not alter the recovery of contractile forces. Contractile depression was observed with 12% LE alone. Concentration-related reduction of tissue BPV concentration by LE was observed in both circulating conditions. CONCLUSIONS: LE induced time- and concentration-dependent recovery of stimulated myocardial contractions from BPV-induced asystole. The lipid uptake effect, along with other undefined mechanisms of LE, seems to contribute to the recovery of contractile function; however, the LE effect on myocardial metabolism is less likely involved at this concentration (500 μM) of BPV. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | ANESTHESIA AND ANALGESIA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Anesthetics, Local/adverse effects | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Blood Pressure | - |
dc.subject.MESH | Bupivacaine/adverse effects* | - |
dc.subject.MESH | Emulsions/pharmacology | - |
dc.subject.MESH | Fat Emulsions, Intravenous/pharmacology | - |
dc.subject.MESH | Glycine/administration & dosage | - |
dc.subject.MESH | Glycine/analogs & derivatives | - |
dc.subject.MESH | Guinea Pigs | - |
dc.subject.MESH | Heart/drug effects* | - |
dc.subject.MESH | Heart Arrest/chemically induced* | - |
dc.subject.MESH | Heart Arrest, Induced/methods | - |
dc.subject.MESH | Lipids/pharmacology* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Myocardial Contraction/drug effects* | - |
dc.subject.MESH | Myocardium/metabolism | - |
dc.subject.MESH | Phospholipids/pharmacology | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Soybean Oil/pharmacology | - |
dc.subject.MESH | Time Factors | - |
dc.title | Intralipid Restoration of Myocardial Contractions Following Bupivacaine-Induced Asystole: Concentration- and Time-Dependence In Vitro | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Anesthesiology and Pain Medicine | - |
dc.contributor.googleauthor | Park, Wyun Kon | - |
dc.contributor.googleauthor | Kim, Hyun Soo | - |
dc.contributor.googleauthor | Kim, Soo Hwan | - |
dc.contributor.googleauthor | Jung, Ja Rang | - |
dc.contributor.googleauthor | Lynch, Carl III | - |
dc.contributor.googleauthor | Min, Nar Hyun | - |
dc.identifier.doi | 10.1213/ANE.0000000000002124 | - |
dc.contributor.localId | A04565 | - |
dc.contributor.localId | A01593 | - |
dc.relation.journalcode | J00144 | - |
dc.identifier.eissn | 1526-7598 | - |
dc.identifier.pmid | 28537978 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000539-201707000-00020&LSLINK=80&D=ovft | - |
dc.contributor.alternativeName | Min, Nar Hyun | - |
dc.contributor.alternativeName | Park, Wyun Kon | - |
dc.contributor.affiliatedAuthor | Min, Nar Hyun | - |
dc.contributor.affiliatedAuthor | Park, Wyun Kon | - |
dc.citation.volume | 125 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 91 | - |
dc.citation.endPage | 100 | - |
dc.identifier.bibliographicCitation | ANESTHESIA AND ANALGESIA, Vol.125(1) : 91-100, 2017 | - |
dc.identifier.rimsid | 38288 | - |
dc.type.rims | ART | - |
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