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Diabetes self-assessment score and the development of diabetes A 10-year prospective study

DC Field Value Language
dc.contributor.author강은석-
dc.contributor.author김규리-
dc.contributor.author이병완-
dc.contributor.author이용호-
dc.contributor.author차봉수-
dc.date.accessioned2018-07-20T07:30:12Z-
dc.date.available2018-07-20T07:30:12Z-
dc.date.issued2017-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160228-
dc.description.abstractTo verify that the Korean Diabetes Score (KDS), a self-assessment, predicts the risk of diabetes in various comprehensive risk models, and to investigate factors that enhance its predictive ability in a large cohort. We analyzed 8735 adults without diabetes in the Korean Genome and Epidemiology Study, an ongoing large community-based 10-year cohort study. Incident diabetes was defined as fasting blood glucose ≥126 mg/dL or postload 2-hour glucose ≥200 mg/dL by 75 g oral glucose tolerance test conducted biennually, or currently taking medication for diabetes. Hazard ratios (HRs) using Cox regression were calculated for relative risk of developing diabetes as associated with the KDS, and performance of risk models was assessed by area under the receiver-operating characteristic curve (AUC). Of 8735 participants, 1497 (17.1%) developed diabetes over 10 years. The prevalence of incident diabetes was 10.3% in people with a KDS <5 and was 21.8% in those with KDS ≥5 (P < .001). Increasing KDS was significantly associated with developing diabetes (adjusted HR: 1.13; 95% confidence interval:1.09,1.18). The comprehensive prediction model with KDS added to fasting glucose, glycated hemoglobin, postload 2-hour glucose, and triglyceride showed a markedly higher AUC (0.782) compared to KDS alone (0.641). A low insulinogenic index (IGI) level, but not insulin resistance, was a significant determinant of developing diabetes in subjects who had baseline KDS < 5. We confirmed that KDS as a 10-year risk model to predict diabetes becomes more potent when added to relevant laboratory parameters. Beta-cell function as assessed by IGI should be taken into account when predicting diabetes using the KDS.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHArea Under Curve-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHBody Mass Index-
dc.subject.MESHDiabetes Mellitus/blood-
dc.subject.MESHDiabetes Mellitus/diagnosis-
dc.subject.MESHDiabetes Mellitus/epidemiology-
dc.subject.MESHDiagnostic Self Evaluation-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProspective Studies-
dc.subject.MESHROC Curve-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk-
dc.titleDiabetes self-assessment score and the development of diabetes A 10-year prospective study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorGyuri Kim-
dc.contributor.googleauthorYong-ho Lee-
dc.contributor.googleauthorByung-Wan Lee-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorIn-Kyu Lee-
dc.contributor.googleauthorBong-Soo Cha-
dc.contributor.googleauthorDae Jung Kim-
dc.identifier.doi10.1097/MD.0000000000007067-
dc.contributor.localIdA00068-
dc.contributor.localIdA00322-
dc.contributor.localIdA02796-
dc.contributor.localIdA02989-
dc.contributor.localIdA03996-
dc.relation.journalcodeJ02214-
dc.identifier.eissn1536-5964-
dc.identifier.pmid28591043-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, Gyuri-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.contributor.affiliatedAuthorKim, Gyuri-
dc.contributor.affiliatedAuthorLee, Byung Wan-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.citation.volume96-
dc.citation.number23-
dc.citation.startPagee7067-
dc.identifier.bibliographicCitationMEDICINE, Vol.96(23) : e7067, 2017-
dc.identifier.rimsid39084-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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