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Effect of gemigliptin on glycaemic variability in patients with type 2 diabetes (STABLE study)

Authors
 Se E. Park  ;  Byung W. Lee  ;  Jae H. Kim  ;  Woo J. Lee  ;  Jae H. Cho  ;  Chang H. Jung  ;  Seung H. Lee  ;  Sunghwan Suh  ;  Gwong C. Hur  ;  Sung H. Kim  ;  Young H. Jang  ;  Cheol Y. Park  ;  STABLE Study Group 
Citation
 DIABETES OBESITY & METABOLISM, Vol.19(6) : 892-896, 2017 
Journal Title
 DIABETES OBESITY & METABOLISM 
ISSN
 1462-8902 
Issue Date
2017
Keywords
dipeptidyl peptidase-4 inhibition ; gemigliptin ; glycaemic variability ; type 2 diabetes
Abstract
The aim of this study was to evaluate the effect of gemigliptin vs sitagliptin or glimepiride as initial combination therapy with metformin on glycaemic variability and to assess the correlation between glycaemic variability reduction and the dipeptidyl peptidase-4 (DPP-4) inhibition in patients with type 2 diabetes. This multicentre, randomized, active-controlled, open-label exploratory study included 69 patients with HbA1c > 7.5%. Subjects were randomized to receive gemigliptin 50 mg (n = 24), sitagliptin 100 mg (n = 23) or glimepiride 2 mg (n = 22) for 12 weeks. After 12 weeks, the change in mean amplitude of glycaemic excursion (MAGE) compared with baseline was significantly lower in the DPP-4 inhibitor groups compared with that in patients who received glimepiride. Furthermore, the standard deviation (SD) of glucose was significantly lower in patients who received gemigliptin than that in patients who received sitagliptin or glimepiride. The DPP-4 inhibition was significantly correlated with changes in MAGE and SD of glucose. In conclusion, gemigliptin and sitagliptin were more effective than glimepiride in reducing glycaemic variability as initial combination therapy with metformin in patients with type 2 diabetes, and the DPP-4 inhibition was associated with a reduction in glycaemic variability.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1111/dom.12869
DOI
10.1111/dom.12869
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Byung Wan(이병완) ORCID logo https://orcid.org/0000-0002-9899-4992
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160216
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