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Change in Renal Function among HIV-Infected Koreans Receiving Tenofovir Disoproxil Fumarate-Backbone Antiretroviral Therapy: A 3-Year Follow-Up Study.

DC FieldValueLanguage
dc.contributor.author구남수-
dc.contributor.author김준명-
dc.contributor.author송영구-
dc.contributor.author이경화-
dc.contributor.author정수진-
dc.contributor.author최준용-
dc.contributor.author한상훈-
dc.date.accessioned2018-07-20T07:29:29Z-
dc.date.available2018-07-20T07:29:29Z-
dc.date.issued2017-
dc.identifier.issn0513-5796-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/160214-
dc.description.abstractPURPOSE: Tenofovir disoproxil fumarate (TDF) is commonly prescribed as a fixed-dose, co-formulated antiretroviral drug for HIV-1 infection. The major concern of long-term TDF use is renal dysfunction. However, little is known about the long-term patterns of changes in renal function in HIV-infected Koreans receiving TDF. MATERIALS AND METHODS: We prospectively followed 50 HIV-infected Koreans, performing laboratory tests every 3 months during the first year and every 6 months for the next 2 years. Urine N-acetyl-β-D-glucosaminidase (NAG) and plasma cystatin-C were measured using samples collected in the first year. Data on renal function were retrospectively collected on HIV-infected patients receiving first-line TDF (n=40) and in antiretroviral therapy (ART)-naïve patients (n=24) for 3 years. Renal function was evaluated as estimated glomerular filtration rate (eGFR) from serum creatinine [Modification of Diet in Renal Disease (MDRD)] and cystatin-C. RESULTS: The eGFR (cystatin-C) showed significant changes from 0 to 48 wks (p=0.002), with the lowest levels at 24 wks (84.3±18.8 mL/min vs. 90.3±22.5 mL/min, p=0.021 by post hoc test). Urine NAG levels did not differ at 0, 12, 24, and 48 wks, although eGFR (MDRD) significantly decreased from 0 (98.7±18.9 mL/min/1.73 m²) to 144 wks (89.0±14.7 mL/min/1.73 m²) (p=0.010). The first-line TDF group had significantly lower eGFR (MDRD) than the ART-naïve group at 144 wks (89.7 mL/min/1.73 m² vs. 98.4 mL/min/1.73 m², p=0.036). Thirteen (26%) participants experienced a decrease in renal impairment of 10 mL/min/1.73 m² in eGFR (MDRD) at 144 wks. CONCLUSION: These data suggest that clinically meaningful renal injury can develop in HIV-infected Koreans receiving long-term TDF.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherYonsei University-
dc.relation.isPartOfYONSEI MEDICAL JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAnti-HIV Agents/pharmacology-
dc.subject.MESHAnti-HIV Agents/therapeutic use*-
dc.subject.MESHDiet-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHIV Infections/drug therapy*-
dc.subject.MESHHIV Infections/physiopathology*-
dc.subject.MESHHIV-1-
dc.subject.MESHHumans-
dc.subject.MESHKidney/drug effects-
dc.subject.MESHKidney/physiopathology*-
dc.subject.MESHKidney Function Tests*-
dc.subject.MESHKidney Tubules/drug effects-
dc.subject.MESHKidney Tubules/physiopathology-
dc.subject.MESHMale-
dc.subject.MESHTenofovir/pharmacology-
dc.subject.MESHTenofovir/therapeutic use*-
dc.titleChange in Renal Function among HIV-Infected Koreans Receiving Tenofovir Disoproxil Fumarate-Backbone Antiretroviral Therapy: A 3-Year Follow-Up Study.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorKyoung Hwa Lee-
dc.contributor.googleauthorJi Un Lee-
dc.contributor.googleauthorNam Su Ku-
dc.contributor.googleauthorSu Jin Jeong-
dc.contributor.googleauthorSang Hoon Han-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorYoung Goo Song-
dc.contributor.googleauthorJune Myung Kim-
dc.identifier.doi10.3349/ymj.2017.58.4.770-
dc.contributor.localIdA00189-
dc.contributor.localIdA00953-
dc.contributor.localIdA02037-
dc.contributor.localIdA04620-
dc.contributor.localIdA03638-
dc.contributor.localIdA04191-
dc.contributor.localIdA04286-
dc.relation.journalcodeJ02813-
dc.identifier.eissn1976-2437-
dc.identifier.pmid28540990-
dc.subject.keywordHIV-
dc.subject.keywordanti-retroviral therapy-
dc.subject.keywordcystatin-C-
dc.subject.keywordeGFR-
dc.subject.keywordrenal toxicity-
dc.subject.keywordtenofovir-
dc.contributor.alternativeNameKu, Nam Su-
dc.contributor.alternativeNameKim, June Myung-
dc.contributor.alternativeNameSong, Young Goo-
dc.contributor.alternativeNameLee, Kyoung Hwa-
dc.contributor.alternativeNameJeong, Su Jin-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.alternativeNameHan, Sang Hoon-
dc.contributor.affiliatedAuthorKu, Nam Su-
dc.contributor.affiliatedAuthorKim, June Myung-
dc.contributor.affiliatedAuthorSong, Young Goo-
dc.contributor.affiliatedAuthorLee, Kyoung Hwa-
dc.contributor.affiliatedAuthorJeong, Su Jin-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.contributor.affiliatedAuthorHan, Sang Hoon-
dc.citation.volume58-
dc.citation.number4-
dc.citation.startPage770-
dc.citation.endPage777-
dc.identifier.bibliographicCitationYONSEI MEDICAL JOURNAL, Vol.58(4) : 770-777, 2017-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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