Cited 44 times in
New Prostate Cancer Grading System Predicts Long-term Survival Following Surgery for Gleason Score 8-10 Prostate Cancer.
DC Field | Value | Language |
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dc.contributor.author | 함원식 | - |
dc.date.accessioned | 2018-07-20T07:28:26Z | - |
dc.date.available | 2018-07-20T07:28:26Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0302-2838 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/160196 | - |
dc.description.abstract | BACKGROUND: The newly proposed five-tiered prostate cancer grading system (PCGS) divides Gleason score (GS) 8-10 disease into GS 8 and GS 9-10 on the basis of biochemical recurrence (BCR) following radical prostatectomy (RP) as an outcome. However, BCR does not necessarily portend worse survival outcomes. OBJECTIVE: To assess the significance of distinguishing GS 8 versus 9-10 disease in terms of long-term survival outcomes for both the preoperative setting using biopsy (Bx) GS and the postoperative setting with RP GS. DESIGN, SETTING, AND PARTICIPANTS: Of 23918 men who underwent RP between 1984 and 2014, there were 721 men with biopsy GS 8-10, and 1047 men with RP GS 8-10. OUTCOME MEASURES AND STATISTICAL ANALYSIS: Clinicopathologic characteristics were compared between men with GS 8 and those with GS 9-10. We compared all-cause mortality (ACM) and prostate cancer-specific mortality (PCSM) risk between the groups using Cox regression and competing-risks analyses, adjusting for other perioperative variables and death from other causes as the competing event. RESULTS AND LIMITATIONS: Compared to men with GS 8, men with GS 9-10 had later RP year and higher pathologic stage. Among men with Bx GS 8-10, 115 died (82 due to PC) with median follow-up of 3 yr (interquartile range [IQR] 1-7) for both overall and cancer-specific survival. Of men with RP GS 8-10, 221 died (151 due to PC) with median follow-up of 4 yr (IQR 2-8) and 4 yr (IQR 2-9) for overall and cancer-specific survival, respectively. PC-specific survival rates were significantly lower for men with GS 9-10 compared to men with GS 8 for both Bx (hazard ratio [HR] 2.13, 95% confidence interval [CI] 1.37-3.30; p<0.01) and RP GS (HR 2.38, 95% CI 1.74-3.28; p<0.01). This association persisted in multivariable models after adjusting for perioperative variables. CONCLUSIONS: Men with GS 9-10 had higher ACM and PCSM rates compared to those with GS 8. GS 8 and GS 9-10 PC should be considered separately in both the preoperative and postoperative setting as suggested by the new PCGS. PATIENT SUMMARY: The prostate cancer grading system can predict mortality risk after radical prostatectomy (RP) for men with Gleason score 8-10 disease based on both biopsy and RP Gleason scores. There are significant differences in all-cause mortality and prostate cancer-specific mortality following surgery between men with Gleason score 8 and those with Gleason score 9-10 disease. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | EUROPEAN UROLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biopsy | - |
dc.subject.MESH | Cancer Survivors | - |
dc.subject.MESH | Cause of Death | - |
dc.subject.MESH | Decision Support Techniques* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Grading/methods* | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Prostatectomy*/adverse effects | - |
dc.subject.MESH | Prostatectomy*/mortality | - |
dc.subject.MESH | Prostatic Neoplasms/mortality | - |
dc.subject.MESH | Prostatic Neoplasms/pathology | - |
dc.subject.MESH | Prostatic Neoplasms/surgery* | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | New Prostate Cancer Grading System Predicts Long-term Survival Following Surgery for Gleason Score 8-10 Prostate Cancer. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Urology | - |
dc.contributor.googleauthor | Won Sik Ham | - |
dc.contributor.googleauthor | Heather J. Chalfin | - |
dc.contributor.googleauthor | Zhaoyong Feng | - |
dc.contributor.googleauthor | Bruce J. Trock | - |
dc.contributor.googleauthor | Jonathan I. Epstein | - |
dc.contributor.googleauthor | Carling Cheung | - |
dc.contributor.googleauthor | Elizabeth Humphreys | - |
dc.contributor.googleauthor | Alan W. Partin | - |
dc.contributor.googleauthor | Misop Han | - |
dc.identifier.doi | 10.1016/j.eururo.2016.11.006 | - |
dc.contributor.localId | A04337 | - |
dc.relation.journalcode | J00854 | - |
dc.identifier.eissn | 1873-7560 | - |
dc.identifier.pmid | 27876305 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0302283816308065 | - |
dc.subject.keyword | Gleason score | - |
dc.subject.keyword | Mortality | - |
dc.subject.keyword | Prostate cancer | - |
dc.contributor.alternativeName | Ham, Won Sik | - |
dc.contributor.affiliatedAuthor | Ham, Won Sik | - |
dc.citation.volume | 71 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 907 | - |
dc.citation.endPage | 912 | - |
dc.identifier.bibliographicCitation | EUROPEAN UROLOGY, Vol.71(6) : 907-912, 2017 | - |
dc.identifier.rimsid | 39024 | - |
dc.type.rims | ART | - |
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