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STAT3-induced WDR1 overexpression promotes triple-negative breast cancer cell migration

Other Titles
 STAT3 유도 WDR1 과발현이 삼중음성 유방암 세포 이동성에 미치는 영향 
Authors
 이주현 
Degree
박사
Issue Date
2018
Description
Department of Medical Science/박사
Abstract
WD repeat domain 1 (WDR1), a protein that assists cofilin-mediated actin filament disassembly, is overexpressed in the invading front of invasive ductal carcinoma (IDC), but its implication of overexpression and how to be regulated have not been studied. In our study, we demonstrated that STAT3 bound to the 5' upstream sequence (-1971 to -1964), a putative promoter region, of WDR1 gene, and its activation induced WDR1 overexpression in breast cancer cells. The exogenous overexpression of WDR1 increased the migration of MDA-MB-231, which was attenuated by WDR1 knockdown. In the analysis of breast cancer patients, WDR1 overexpression was associated with a shorter distant metastasis-free survival (DMFS), more specifically in basal-like tumors. (C) 2016 Elsevier Inc. All rights reserved.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 3. Dissertation
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/160051
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