136 276

Cited 7 times in

Prominent IL-12 production and tumor reduction in athymic nude mice after Toxoplasma gondii lysate antigen treatment

Authors
 Kyoung-Ho Pyo  ;  Bong-Kwang Jung  ;  Chun-Feng Xin  ;  You-Won Lee  ;  Jong-Yil Chai  ;  Eun-Hee Shin 
Citation
 KOREAN JOURNAL OF PARASITOLOGY, Vol.52(6) : 605-612, 2014 
Journal Title
KOREAN JOURNAL OF PARASITOLOGY
ISSN
 0023-4001 
Issue Date
2014
Keywords
Animals ; Antigens, Protozoan/immunology* ; Disease Models, Animal ; Immunity, Innate ; Immunotherapy/methods* ; Interleukin-12/blood* ; Macrophages/immunology ; Mice, Inbred BALB C ; Mice, Nude ; Myeloid Differentiation ; Factor 88/analysis ; Neoplasms/pathology ; Neoplasms/therapy* ; Toxoplasma/immunology* ; Treatment Outcome
Abstract
Toxoplasma gondii is an intracellular protozoan parasite that causes a Th1 cellular immunity. Our previous study showed that T. gondii lysate antigen (TLA) treatment in S180 tumor-bearing mice resulted in tumor reduction by suppressing CD31 expression, a marker of angiogenesis. In the present study, to investigate tumor suppressive effect of TLA under the absence of T lymphocytes, athymic nude mice were compared with euthymic mice in the anti-tumorigenic effect triggered by TLA in CT26 tumors. According to the results, intratumorally injected TLA reduced tumor growth and TIMP-1 level, a metastatic marker, in both euthymic and athymic mice. TLA treatment led to a sharp increase in IL-12 expression in serum cytokine profiling of athymic mice, and increased MyD88 signals in macrophages derived from the bone marrow, implying the activation of innate immunity. The selective induction of IL-12 by TLA treatment had an anti-tumorigenic effect.
Files in This Item:
T201406467.pdf Download
DOI
10.3347/kjp.2014.52.6.605
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Pyo, Kyoung Ho(표경호) ORCID logo https://orcid.org/0000-0001-5428-0288
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158645
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links