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Migration of neutrophils targeting amyloid plaques in Alzheimer's disease mouse model

Authors
 Sung Hoon Baika  ;  Moon-Yong Cha  ;  Young-Min Hyun  ;  Hansang Cho  ;  Bashar Hamza  ;  Dong Kyu Kim  ;  Sun-Ho Han  ;  Heesun Choi  ;  Kyung Ho Kim  ;  Minho Moon  ;  Jeewoo Lee  ;  Minsoo Kim  ;  Daniel Irimia  ;  Inhee Mook-Jung 
Citation
 NEUROBIOLOGY OF AGING, Vol.35(6) : 1286-1292, 2014 
Journal Title
 NEUROBIOLOGY OF AGING 
ISSN
 0197-4580 
Issue Date
2014
MeSH
Alzheimer Disease/immunology* ; Animals ; Brain/immunology* ; Cell Movement/immunology* ; Cells, Cultured ; Disease Models, Animal ; Humans ; Mice ; Mice, Transgenic ; Microscopy/methods ; Molecular Imaging/methods ; Neutrophils/immunology* ; Plaque, Amyloid/immunology*
Abstract
Immune responses in the brain are thought to play a role in disorders of the central nervous system, but an understanding of the process underlying how immune cells get into the brain and their fate there remains unclear. In this study, we used a 2-photon microscopy to reveal that neutrophils infiltrate brain and migrate toward amyloid plaques in a mouse model of Alzheimer's disease. These findings suggest a new molecular process underlying the pathophysiology of Alzheimer's disease
Files in This Item:
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DOI
10.1016/j.neurobiolaging.2014.01.003
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Hyun, Young-Min(현영민) ORCID logo https://orcid.org/0000-0002-0567-2039
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/158595
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