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Comprehensive molecular characterization of gastric adenocarcinoma

DC Field Value Language
dc.contributor.author정재호-
dc.date.accessioned2018-05-10T06:45:55Z-
dc.date.available2018-05-10T06:45:55Z-
dc.date.issued2014-
dc.identifier.issn0028-0836-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/158586-
dc.description.abstractGastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein-Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfNATURE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/classification*-
dc.subject.MESHAdenocarcinoma/genetics*-
dc.subject.MESHAdenocarcinoma/virology-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHGenome, Human/genetics*-
dc.subject.MESHHerpesvirus 4, Human/genetics-
dc.subject.MESHHerpesvirus 4, Human/isolation & purification-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMutation-
dc.subject.MESHProteome-
dc.subject.MESHStomach Neoplasms/classification*-
dc.subject.MESHStomach Neoplasms/genetics*-
dc.subject.MESHStomach Neoplasms/virology-
dc.titleComprehensive molecular characterization of gastric adenocarcinoma-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorCancer Genome Atlas Research Network-
dc.identifier.doi10.1038/nature13480-
dc.contributor.localIdA03717-
dc.relation.journalcodeJ02289-
dc.identifier.eissn1476-4687-
dc.identifier.pmid25079317-
dc.contributor.alternativeNameCheong, Jae Ho-
dc.contributor.affiliatedAuthorCheong, Jae Ho-
dc.citation.volume513-
dc.citation.number7517-
dc.citation.startPage202-
dc.citation.endPage209-
dc.identifier.bibliographicCitationNATURE, Vol.513(7517) : 202-209, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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