Cited 4549 times in
Comprehensive molecular characterization of gastric adenocarcinoma
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 정재호 | - |
dc.date.accessioned | 2018-05-10T06:45:55Z | - |
dc.date.available | 2018-05-10T06:45:55Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0028-0836 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/158586 | - |
dc.description.abstract | Gastric cancer is a leading cause of cancer deaths, but analysis of its molecular and clinical characteristics has been complicated by histological and aetiological heterogeneity. Here we describe a comprehensive molecular evaluation of 295 primary gastric adenocarcinomas as part of The Cancer Genome Atlas (TCGA) project. We propose a molecular classification dividing gastric cancer into four subtypes: tumours positive for Epstein-Barr virus, which display recurrent PIK3CA mutations, extreme DNA hypermethylation, and amplification of JAK2, CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2); microsatellite unstable tumours, which show elevated mutation rates, including mutations of genes encoding targetable oncogenic signalling proteins; genomically stable tumours, which are enriched for the diffuse histological variant and mutations of RHOA or fusions involving RHO-family GTPase-activating proteins; and tumours with chromosomal instability, which show marked aneuploidy and focal amplification of receptor tyrosine kinases. Identification of these subtypes provides a roadmap for patient stratification and trials of targeted therapies. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isPartOf | NATURE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/classification* | - |
dc.subject.MESH | Adenocarcinoma/genetics* | - |
dc.subject.MESH | Adenocarcinoma/virology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | Genome, Human/genetics* | - |
dc.subject.MESH | Herpesvirus 4, Human/genetics | - |
dc.subject.MESH | Herpesvirus 4, Human/isolation & purification | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mutation | - |
dc.subject.MESH | Proteome | - |
dc.subject.MESH | Stomach Neoplasms/classification* | - |
dc.subject.MESH | Stomach Neoplasms/genetics* | - |
dc.subject.MESH | Stomach Neoplasms/virology | - |
dc.title | Comprehensive molecular characterization of gastric adenocarcinoma | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Surgery | - |
dc.contributor.googleauthor | Cancer Genome Atlas Research Network | - |
dc.identifier.doi | 10.1038/nature13480 | - |
dc.contributor.localId | A03717 | - |
dc.relation.journalcode | J02289 | - |
dc.identifier.eissn | 1476-4687 | - |
dc.identifier.pmid | 25079317 | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | Cheong, Jae Ho | - |
dc.citation.volume | 513 | - |
dc.citation.number | 7517 | - |
dc.citation.startPage | 202 | - |
dc.citation.endPage | 209 | - |
dc.identifier.bibliographicCitation | NATURE, Vol.513(7517) : 202-209, 2014 | - |
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